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JCB65: Mitochondria

In the sixth collection celebrating our 65th anniversary, we revisit historical papers describing the metabolic functions of mitochondria such as initial studies demonstrating that the outer mitochondrial membrane houses the electron transport chain and consists of cytochrome enzymes. We also explore early studies that shaped the mitochondria dynamics field, including the identification of Fzo1 as a central fusion component in yeast, the characterization of the Mfn1/2-/- mice as well as Drp1-/- mice. We also include foundational studies exploring the spatial organization of mitochondrial inner membranes as well as studies of mitochondria stress responses, motility, and mitochondrial contacts with other organelles. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at [email protected]. Find more 65th anniversary collections or browse our From the Archive series.

Image from Chen et al., 2003.

Article

Mitochondrial CoQ domains at ER–mitochondria contacts

Kelly Subramanian; Adam Jochem; Maxence Le Vasseur; Samantha Lewis; Brett R. Paulson; Thiruchelvi R. Reddy; Jason D. Russell; Joshua J. Coon; David J. Pagliarini; Jodi Nunnari

https://doi.org/10.1083/jcb.201808044

Article

ATF4 regulates mitochondrial stress response

Pedro M. Quirós; Miguel A. Prado; Nicola Zamboni; Davide D’Amico; Robert W. Williams; Daniel Finley; Steven P. Gygi; Johan Auwerx

https://doi.org/10.1083/jcb.201702058

Article

Mitochondrial transport facilitates regeneration

Bing Zhou; Panpan Yu; Mei-Yao Lin; Tao Sun; Yanmin Chen; Zu-Hang Sheng

https://doi.org/10.1083/jcb.201605101

Report

Ltc1 is an ER-localized sterol transfer protein

Andrew Murley; Reta D. Sarsam; Alexandre Toulmay; Justin Yamada; William A. Prinz; Jodi Nunnari

https://doi.org/10.1083/jcb.201502033

Article

F-actin and mitochondrial fission

Sunan Li; Shan Xu; Brian A. Roelofs; Liron Boyman; W. Jonathan Lederer; Hiromi Sesaki; Mariusz Karbowski

https://doi.org/10.1083/jcb.201404050

Article

Regulation of axonal mitochondrial transport

Yanmin Chen; Zu-Hang Sheng

https://doi.org/10.1083/jcb.201302040

Article

Myosin V regulates inheritance of diverse cargoes

P. Taylor Eves; Yui Jin; Matthew Brunner; Lois S. Weisman

https://doi.org/10.1083/jcb.201201024

Tools

MITO-MAP reveals inner membrane organization complex

Suzanne Hoppins; Sean R. Collins; Ann Cassidy-Stone; Eric Hummel; Rachel M. DeVay; Laura L. Lackner; Benedikt Westermann; Maya Schuldiner; Jonathan S. Weissman; Jodi Nunnari

https://doi.org/10.1083/jcb.201107053

Article

Mff is essential for mitochondrial recruitment of Drp1

Hidenori Otera; Chunxin Wang; Megan M. Cleland; Kiyoko Setoguchi; Sadaki Yokota; Richard J. Youle; Katsuyoshi Mihara

https://doi.org/10.1083/jcb.201007152

Report

ΔΨ_m-dependent cleavage of PINK1 mediated by PARL

Seok Min Jin; Michael Lazarou; Chunxin Wang; Lesley A. Kane; Derek P. Narendra; Richard J. Youle

https://doi.org/10.1083/jcb.201008084

Article

ER dynamics occur on acetylated microtubules

Jonathan R. Friedman; Brant M. Webster; David N. Mastronarde; Kristen J. Verhey; Gia K. Voeltz

https://doi.org/10.1083/jcb.200911024

Article

Control of OPA1 by m-AAA protease and OMA1

Sarah Ehses; Ines Raschke; Giuseppe Mancuso; Andrea Bernacchia; Stefan Geimer; Daniel Tondera; Jean-Claude Martinou; Benedikt Westermann; Elena I. Rugarli; Thomas Langer

https://doi.org/10.1083/jcb.200906084

Report

Inducible cleavage of OPA1 by OMA1

Brian Head; Lorena Griparic; Mandana Amiri; Shilpa Gandre-Babbe; Alexander M. van der Bliek

https://doi.org/10.1083/jcb.200906083

Report

Junko Wakabayashi; Zhongyan Zhang; Nobunao Wakabayashi; Yasushi Tamura; Masahiro Fukaya; Thomas W. Kensler; Miho Iijima; Hiromi Sesaki

https://doi.org/10.1083/jcb.200903065

Article

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane

Steven M. Claypool; Yavuz Oktay; Pinmanee Boontheung; Joseph A. Loo; Carla M. Koehler

https://doi.org/10.1083/jcb.200801152

Report

Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

Lorena Griparic; Takayuki Kanazawa; Alexander M. van der Bliek

https://doi.org/10.1083/jcb.200704112

Report

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Zhiyin Song; Hsiuchen Chen; Maja Fiket; Christiane Alexander; David C. Chan

https://doi.org/10.1083/jcb.200704110

Article

Dynamic subcompartmentalization of the mitochondrial inner membrane

Frank Vogel; Carsten Bornhövd; Walter Neupert; Andreas S. Reichert

https://doi.org/10.1083/jcb.200605138

Report

Structural and functional features and significance of the physical linkage between ER and mitochondria

György Csordás; Christian Renken; Péter Várnai; Ludivine Walter; David Weaver; Karolyn F. Buttle; Tamás Balla; Carmen A. Mannella; György Hajnóczky

https://doi.org/10.1083/jcb.200604016

Article

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

Elizabeth E. Glater; Laura J. Megeath; R. Steven Stowers; Thomas L. Schwarz

https://doi.org/10.1083/jcb.200601067

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JCB65: Mitochondria

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