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    An electron micrograph shows the accumulation of lysosomal storage material in mouse B cells incapable of targeting lysosomal enzymes via mannose 6-phosphate sorting signals. Otomo et al. reveal that, in the absence of mannose 6 phosphorylation, mouse B cells show impaired antigen processing and presentation and subsequent defects in B cell maturation and antibody production.
    Image © 2015 Otomo et al.
    See page 171.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study shows that a feed-forward signaling loop controls dorsal closure in flies.

People & Ideas

Haynes tracks the mitochondrial unfolded protein response and its ramifications for cellular health.




Arp2 phosphorylation by the kinase NIK increases the actin-nucleating activity of the Arp2/3 complex and is necessary for plasma membrane protrusion in response to EGF.

M6P-dependent transport routes are essential for B cell functions in vivo and humoral immunity in mouse and human.


During mitosis in human cells, separate mechanisms involving Aurora B and CENP-T promote anchoring of the microtubule- and checkpoint-receptor complex KMN at kinetochores.

pH-dependent receptor binding of specific cargo by the Erv41–Erv46 complex in Golgi compartments identifies escaped ER resident proteins that are then returned to the ER in COPI vesicles.

Salt bridges at the dynein–microtubule interface couple microtubule binding to ATPase activation and thereby control the directional movement of dynein

In Chlamydomonas cilia, IFT concentrates soluble tubulin by regulating IFT train occupancy and thereby promotes elongation of axonemal microtubules.

During Drosophila dorsal closure, DPP and JNK signaling form a feed-forward loop that controls the specification and differentiation of leading edge cells to ensure robust morphogenesis.


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