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Cover Image
Cover Image
On the cover
An electron micrograph shows the accumulation of lysosomal storage material in mouse B cells incapable of targeting lysosomal enzymes via mannose 6-phosphate sorting signals. Otomo et al. reveal that, in the absence of mannose 6 phosphorylation, mouse B cells show impaired antigen processing and presentation and subsequent defects in B cell maturation and antibody production.
Image © 2015 Otomo et al.
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In This Issue
In Focus
Putting a kink in a familiar control loop
Study shows that a feed-forward signaling loop controls dorsal closure in flies.
People & Ideas
Cole Haynes: On the trail of mitochondrial dysfunction
Haynes tracks the mitochondrial unfolded protein response and its ramifications for cellular health.
Feature
Review
Report
The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit
Arp2 phosphorylation by the kinase NIK increases the actin-nucleating activity of the Arp2/3 complex and is necessary for plasma membrane protrusion in response to EGF.
Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions
M6P-dependent transport routes are essential for B cell functions in vivo and humoral immunity in mouse and human.
Article
Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores
During mitosis in human cells, separate mechanisms involving Aurora B and CENP-T promote anchoring of the microtubule- and checkpoint-receptor complex KMN at kinetochores.
The Erv41–Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins
pH-dependent receptor binding of specific cargo by the Erv41–Erv46 complex in Golgi compartments identifies escaped ER resident proteins that are then returned to the ER in COPI vesicles.
A flipped ion pair at the dynein–microtubule interface is critical for dynein motility and ATPase activation
Salt bridges at the dynein–microtubule interface couple microtubule binding to ATPase activation and thereby control the directional movement of dynein
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
In Chlamydomonas cilia, IFT concentrates soluble tubulin by regulating IFT train occupancy and thereby promotes elongation of axonemal microtubules.
A DPP-mediated feed-forward loop canalizes morphogenesis during Drosophila dorsal closure
During Drosophila dorsal closure, DPP and JNK signaling form a feed-forward loop that controls the specification and differentiation of leading edge cells to ensure robust morphogenesis.
