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Cover Image
Cover Image
On the cover
Artym et al. reveal that high-density fibrillar collagen (blue) strongly induces the formation of invadopodia (yellow puncta), invasive membrane protrusions containing actin (green) and cortactin (red).
Image © 2015 Artym et al.
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In This Issue
In Focus
A Ror recruit to mammary gland development
Study shows how noncanonical Wnt signaling promotes differentiation and morphogenesis of mammary epithelia.
People & Ideas
Cayetano González: Mothers, daughters, stemness, and cancer
González studies centrosomal inheritance, asymmetric cell division, and cancer.
From the Archive
Mapping out the nuclear pore complex
In 2000, a first-of-its-kind study by Rout et al. provided a comprehensive survey of the nuclear pore’s composition and architecture.
Review
Report
A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations
A novel assay based on expressing FRB-tagged candidate vesicle-binding protein reveals that KIF13A and KIF13B bind preferentially to early endosomes, whereas KIF1A and KIF1Bβ bind preferentially to late endosomes and lysosomes.
Article
Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold
The yeast Nup82 complex forms an unusual asymmetric structure with a dimeric array of subunits that mediate its anchorage to the NPC scaffold and its concomitant interaction with the soluble nucleocytoplasmic transport machinery.
Protein kinase Gin4 negatively regulates flippase function and controls plasma membrane asymmetry
In yeast, the protein kinase Gin4 locally controls plasma membrane lipid asymmetry, which is necessary for optimal cytokinesis.
Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin
Dystroglycan promotes nodogenesis in part through recruitment of perlecan to nodes of Ranvier, where it binds to gliomedin and may thereby promote sodium channel clustering.
Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network
High-density fibrillar collagen matrix induces invadopodia formation in both fibroblasts and carcinoma cell lines through a kindlin2-dependent mechanism that drives local ECM remodeling.
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium
Intricate cross-talk between classical and alternative Wnt signaling pathways includes an essential role for Ror2 in mammary epithelial development and differentiation.
Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice
A novel, unipotent progenitor population in the skin characterized by Atoh1 expression gives rise to Merkel cells both during development and adulthood.
