On the cover
Artym et al. reveal that high-density fibrillar collagen (blue) strongly induces the formation of invadopodia (yellow puncta), invasive membrane protrusions containing actin (green) and cortactin (red).
Image © 2015 Artym et al.
See page 331.
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A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations
A novel assay based on expressing FRB-tagged candidate vesicle-binding protein reveals that KIF13A and KIF13B bind preferentially to early endosomes, whereas KIF1A and KIF1Bβ bind preferentially to late endosomes and lysosomes.
The yeast Nup82 complex forms an unusual asymmetric structure with a dimeric array of subunits that mediate its anchorage to the NPC scaffold and its concomitant interaction with the soluble nucleocytoplasmic transport machinery.
In yeast, the protein kinase Gin4 locally controls plasma membrane lipid asymmetry, which is necessary for optimal cytokinesis.
Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin
Dystroglycan promotes nodogenesis in part through recruitment of perlecan to nodes of Ranvier, where it binds to gliomedin and may thereby promote sodium channel clustering.
High-density fibrillar collagen matrix induces invadopodia formation in both fibroblasts and carcinoma cell lines through a kindlin2-dependent mechanism that drives local ECM remodeling.
Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium
Intricate cross-talk between classical and alternative Wnt signaling pathways includes an essential role for Ror2 in mammary epithelial development and differentiation.
A novel, unipotent progenitor population in the skin characterized by Atoh1 expression gives rise to Merkel cells both during development and adulthood.