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Cover Image
Cover Image
On the cover
The morphology and linear organization of mitochondria (magenta) is disrupted in an adult mouse cardiomyocyte lacking the mitochondrial outer membrane fusion protein Mitofusin 2. T-tubules are labeled green. Mourier et al. reveal that mitochondrial respiration is impaired in the absence of Mitofusin 2 due to a decrease in coenzyme Q levels.
Image © 2015 Mourier et al.
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In This Issue
In Focus
Actin works both sides of the immunological synapse
The cytoskeleton of both T cells and antigen-presenting cells promotes mechanical signaling during T cell activation.
People & Ideas
Thoru Pederson: Spotting novel roles for the nucleolus
Pederson’s career has revolved around the nucleus, nucleolus, and the nucleoproteins that inhabit them.
Feature
Report
The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12
Cdc15 contributes to contractile ring formation and cytokinesis by recruiting the formin Cdc12, which defines a novel cytokinetic function for an F-BAR domain.
Article
Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability
The Asterless N terminus promotes Plk4 homodimerization and autophosphorylation during interphase, whereas its C terminus stabilizes Plk4 during mitosis.
Telomeres and centromeres have interchangeable roles in promoting meiotic spindle formation
Both centromere–centrosome and telomere–centrosome contacts can promote spindle formation during meiosis.
Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels
Mitofusin 2 plays an unexpected role in maintaining the terpenoid biosynthesis pathway and is necessary for mitochondrial coenzyme Q biosynthesis.
F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling
During cell migration, F-actin bundles/filopodia serve as templates for formation and orientation of lamellipodia and prime their stabilization by adhesion-based PI3K signaling.
The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility
The actin-binding proteins moesin and α-actinin-1 limit the lateral mobility and clustering of ICAM-1 in dendritic cells and thereby promote antigen-dependent conjugate formation and T cell priming.
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
The T cell actin network generates mechanical forces that regulate LFA-1 activity at the immunological synapse.
