On the cover
The morphology and linear organization of mitochondria (magenta) is disrupted in an adult mouse cardiomyocyte lacking the mitochondrial outer membrane fusion protein Mitofusin 2. T-tubules are labeled green. Mourier et al. reveal that mitochondrial respiration is impaired in the absence of Mitofusin 2 due to a decrease in coenzyme Q levels.
Image © 2015 Mourier et al.
See page 429.
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The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12
Cdc15 contributes to contractile ring formation and cytokinesis by recruiting the formin Cdc12, which defines a novel cytokinetic function for an F-BAR domain.
Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability
The Asterless N terminus promotes Plk4 homodimerization and autophosphorylation during interphase, whereas its C terminus stabilizes Plk4 during mitosis.
Both centromere–centrosome and telomere–centrosome contacts can promote spindle formation during meiosis.
Mitofusin 2 plays an unexpected role in maintaining the terpenoid biosynthesis pathway and is necessary for mitochondrial coenzyme Q biosynthesis.
F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling
During cell migration, F-actin bundles/filopodia serve as templates for formation and orientation of lamellipodia and prime their stabilization by adhesion-based PI3K signaling.
The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility
The actin-binding proteins moesin and α-actinin-1 limit the lateral mobility and clustering of ICAM-1 in dendritic cells and thereby promote antigen-dependent conjugate formation and T cell priming.
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
The T cell actin network generates mechanical forces that regulate LFA-1 activity at the immunological synapse.