Skip to Main Content

Advertisement

Issues

  • Cover Image

    Cover Image

    issue cover

    On the cover
    The morphology and linear organization of mitochondria (magenta) is disrupted in an adult mouse cardiomyocyte lacking the mitochondrial outer membrane fusion protein Mitofusin 2. T-tubules are labeled green. Mourier et al. reveal that mitochondrial respiration is impaired in the absence of Mitofusin 2 due to a decrease in coenzyme Q levels.
    Image © 2015 Mourier et al.
    See page 429.

  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

The cytoskeleton of both T cells and antigen-presenting cells promotes mechanical signaling during T cell activation.

People & Ideas

Pederson’s career has revolved around the nucleus, nucleolus, and the nucleoproteins that inhabit them.

Feature

Report

Cdc15 contributes to contractile ring formation and cytokinesis by recruiting the formin Cdc12, which defines a novel cytokinetic function for an F-BAR domain.

Article

The Asterless N terminus promotes Plk4 homodimerization and autophosphorylation during interphase, whereas its C terminus stabilizes Plk4 during mitosis.

Both centromere–centrosome and telomere–centrosome contacts can promote spindle formation during meiosis.

Mitofusin 2 plays an unexpected role in maintaining the terpenoid biosynthesis pathway and is necessary for mitochondrial coenzyme Q biosynthesis.

During cell migration, F-actin bundles/filopodia serve as templates for formation and orientation of lamellipodia and prime their stabilization by adhesion-based PI3K signaling.

The actin-binding proteins moesin and α-actinin-1 limit the lateral mobility and clustering of ICAM-1 in dendritic cells and thereby promote antigen-dependent conjugate formation and T cell priming.

The T cell actin network generates mechanical forces that regulate LFA-1 activity at the immunological synapse.

Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal