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Cover Image
Cover Image
On the cover
The ciliary basal bodies (red) of a Tetrahymena thermophila cell are aligned and oriented so that every cilium beats in the same direction. Galati et al. identify a protein, DisAp, that localizes to the kinetodesmal fibers (green) protruding from each basal body and helps the structures respond to mechanical force so that they can maintain the basal bodies′ organization.
Image © 2014 Galati et al.
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In This Issue
In Focus
Osmotic gradient is just the tonic for wounded epithelia
Researchers describe how environmental signals trigger wound repair in zebrafish.
People & Ideas
Dominique Bergmann: Passionate about plant polarity
Bergmann studies stomatal development to discover how plant cells parse polarity and fate.
Report
KIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle
Active recruitment of Aurora B and its counteracting phosphatase PP2A–B56 to the anaphase spindle is promoted by the kinesins MKlp2 and KIF4A, respectively.
Remodeling of secretory compartments creates CUPS during nutrient starvation
Starvation triggers relocation of membranes of the secretory compartments and endosomes to create a compartment called CUPS, which may be involved in processing and secretion of proteins that cannot enter the ER–Golgi pathway.
DisAp-dependent striated fiber elongation is required to organize ciliary arrays
DisAp is a novel kinetodesmal fiber component that is essential for force-dependent fiber elongation and the alignment of basal body orientation in multiciliary arrays.
Article
Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair
Chromatin compaction mediated by CHD3.1 must be counteracted by ACF1–SNF2H and RNF20 in order to allow DNA double-strand break repair in heterochromatin of postreplicative cells.
A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport
Interactions between ankyrin-B and both dynactin and phosphatidylinositol 3-phosphate lipids promote fast axonal transport of organelles.
Thyroid hormone regulates muscle fiber type conversion via miR-133a1
Thyroid hormone promotes slow-to-fast muscle fiber type conversion by inducing miR-133a1 and thereby repressing the expression of the slow muscle determinant TEAD1.
Osmotic surveillance mediates rapid wound closure through nucleotide release
After wounding in zebrafish, osmolarity differences between the interstitial fluid and the external environment trigger ATP release that initiates rapid wound closure through long-range activation of basal epithelial cell motility.
