In This Issue
People & Ideas
An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion
Elmo–Dock complexes are involved not just in integrin-based adhesions but also in the initial formation of strong cadherin-based adhesions through the regulation of local Rho GTPase activity and actin remodeling.
Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration
Redox and Src family kinase signaling in tissue adjacent to a wound coordinates initial attraction of leukocytes and the subsequent repulsion of neutrophils following contact with macrophages to resolve inflammation.
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells
Nuclear BRCA2 is oligomeric and associated with RAD51, possibly sequestering it until it is delivered to DNA damage sites.
A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens
A holin (ChiW) and an endopeptidase (ChiX) operate in tandem as components of a protein secretion system used by the gram-negative bacterium Serratia marcescens to secrete the chitinolytic machinery.
CDK5 activates the tumor suppressor DLC1 by phosphorylating and diminishing the binding of an autoinhibitory region of DLC1 to its Rho-GAP domain and allows it to localize to focal adhesions.
In skeletogenic mesenchyme, SOXC proteins enter the APC–Axin destruction complex to inhibit β-catenin phosphorylation by GSK3 and thereby synergize with canonical WNT signaling to inhibit chondrogenesis.
High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor