On the cover
Human dermal fibroblasts secrete and incorporate a green fluorescent protein-tagged version of the latent TGF-β1 binding protein into extracellular matrix fibrils containing the fibronectin splice variant ED-A FN (red). Klingberg et al. demonstrate that increased matrix organization and enhanced mechanical strain prime latent TGF-β1 for cell contraction-mediated activation. Fibroblast nuclei are shown in blue.
Image © 2014 Klingberg et al.
See page 283.
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Cell biology in development
Pericentric enrichment of condensin on budding yeast chromosomes, which contributes to chromatin compaction and mitotic spindle structure and integrity, is mediated by condensin interaction with tRNA genes and the tRNA-interacting protein dyskerin.
Aurora B phosphorylation of the Polo kinase activation loop disrupts its binding to Map205 and central spindle microtubules, allowing it to be recruited to the site of cytokinesis.
CLUH is a cytosolic mRNA-binding protein that specifically binds a subset of mRNAs encoding mitochondrial proteins and may regulate their localized translation.
Septins promote epithelial motility by reinforcing the crosslinking of lamellar stress fibers and the stability of nascent focal adhesions.
Regulatory brain cytoplasmic RNAs cooperate with eukaryotic initiation factor 4B to couple translation to receptor activation in support of long-term plastic changes in neurons.
In Drosophila, AKT1 and the Dcp-1 caspase calibrate basal autophagy levels and cellular metabolism by regulating Acn stability.
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
Crystallographic analysis of the B core complex of the intraflagellar transport machinery provides insight into the molecular basis of ciliogenesis defects caused by several specific IFT mutations.
A mild strain induced by matrix remodeling mechanically primes latent TGF-β1 for its subsequent activation and release in response to contractile forces.
The LKB1 kinase regulates directional migration in response to extracellular matrix gradients and may inhibit invasive motility by sensing inhibitory matrix cues.