-
Cover Image
Cover Image
On the cover
Human dermal fibroblasts secrete and incorporate a green fluorescent protein-tagged version of the latent TGF-β1 binding protein into extracellular matrix fibrils containing the fibronectin splice variant ED-A FN (red). Klingberg et al. demonstrate that increased matrix organization and enhanced mechanical strain prime latent TGF-β1 for cell contraction-mediated activation. Fibroblast nuclei are shown in blue.
Image © 2014 Klingberg et al.
See page 283. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
In Focus
TGF-β gets primed for action
Study reveals that extracellular matrix remodeling by myofibroblasts enhances the activation of TGF-β.
People & Ideas
Guangshuo Ou: New perspectives on Q cell biology
Ou studies asymmetric stem cell division and differentiation in C. elegans Q neuroblasts.
Review
Report
Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis
Pericentric enrichment of condensin on budding yeast chromosomes, which contributes to chromatin compaction and mitotic spindle structure and integrity, is mediated by condensin interaction with tRNA genes and the tRNA-interacting protein dyskerin.
Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis
Aurora B phosphorylation of the Polo kinase activation loop disrupts its binding to Map205 and central spindle microtubules, allowing it to be recruited to the site of cytokinesis.
CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins
CLUH is a cytosolic mRNA-binding protein that specifically binds a subset of mRNAs encoding mitochondrial proteins and may regulate their localized translation.
Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility
Septins promote epithelial motility by reinforcing the crosslinking of lamellar stress fibers and the stability of nascent focal adhesions.
Article
Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control
Regulatory brain cytoplasmic RNAs cooperate with eukaryotic initiation factor 4B to couple translation to receptor activation in support of long-term plastic changes in neurons.
Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy
In Drosophila, AKT1 and the Dcp-1 caspase calibrate basal autophagy levels and cellular metabolism by regulating Acn stability.
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
Crystallographic analysis of the B core complex of the intraflagellar transport machinery provides insight into the molecular basis of ciliogenesis defects caused by several specific IFT mutations.
Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation
A mild strain induced by matrix remodeling mechanically primes latent TGF-β1 for its subsequent activation and release in response to contractile forces.
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues
The LKB1 kinase regulates directional migration in response to extracellular matrix gradients and may inhibit invasive motility by sensing inhibitory matrix cues.
