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Dual-tagged proteins give a more complete picture of Notch receptor trafficking pathways.

People & Ideas

Fletcher specializes in reconstituting subcellular structures to test their behavior.



SAT III RNA binds to the kinetochore component CENP-C and is required for correct assembly and function of the kinetochore at centromeres.

Real-time analysis of fluorescently tagged versions of Notch and its trafficking regulator Sanpodo identify distinct pools of the two proteins and reveal a Numb-dependent sorting of Sanpodo to late endosomes.

β3-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.

The Usher syndrome type 3–associated protein clarin-1 is functionally important for mechanotransduction channel activity and for proper localization of synaptic components in zebrafish hair cells.


A new system for generating cellular protein assemblies of defined spacing and composition reveals that kinesin motors located near each other function independently rather than cooperatively and are influenced primarily by the characteristics of the microtubule track on which they are moving.

The use of micropatterned surfaces that bind HaloTag fusion proteins allows spatial organization of plasma membrane proteins for efficient visualization and quantification of protein–protein interactions in live cells.

A new pH-sensitive red fluorescent protein called pHuji, in combination with green fluorescent superecliptic pHluorin, allows two-color detection of endocytic events in live cells.

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