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Cover Image
Cover Image
On the cover
Structured illumination microscopy of multiciliated tracheal epithelial cells shows the presence of numerous centrioles (green, labeled with GFP-Centrin 2) surrounded by rings of the distal appendage protein CEP164 (red). Burke et al. reveal that CEP164 recruits a protein called Chibby that helps centrioles dock with the plasma membrane during ciliogenesis by promoting the formation of a membranous cap known as the ciliary vesicle.
Image © 2014 Burke et al.
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In This Issue
In Focus
How mitosis keeps itself in order
Researchers describe how multiple mechanisms ensure that mitotic proteins are degraded in the correct sequence.
People & Ideas
Raphael Valdivia: How Chlamydia settles in
Valdivia studies how the pathogen Chlamydia trachomatis interacts with its host cell.
Editorial
Review
Article
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis
To ensure proper mitotic progression, robust ordering of the destruction of APC/CCdc20 substrates is driven by the integration of molecular mechanisms ranging from phosphorylation-dependent interaction with substrates to sensing of the status of the spindle assembly checkpoint.
The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation
In both Xenopus laevis egg extract and human cells, an increase in cytosolic calcium activates the endogenous ribonuclease XendoU/hEndoU, which localizes to the ER, promotes RNA cleavage and RNP removal, and induces ER network assembly.
Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p
The exocyst subunit Exo70p is targeted to cortical sites in an actin-independent manner through a direct interaction with the polarity determinant Bem1p.
Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts
Dynamin function is essential for cell–cell fusion in both osteoclast precursors and myoblasts in part through its effects on endocytosis.
Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins
The budding yeast kinase Hrr25 regulates two selective autophagy–related pathways by phosphorylating degradation target receptors and thereby promoting their interaction with Atg11 and the formation of autophagosomal membrane.
Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells
Apical membrane organization of nonconfluent epithelial cells is driven by a dynamic network of actin and myosin II filaments.
Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation
In the early stages of cilia formation in the mouse airway epithelium, Chibby is recruited to the distal appendages of centrioles and is necessary for efficient ciliary vesicle formation and basal body docking at the apical cell membrane.
Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy
In Duchenne muscular dystrophy, asynchronous regeneration in microenvironments within muscle tissue results in development of fibrosis in lieu of global muscle recovery.
