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In Focus

Researchers stumble on new domain within the nucleus.

People & Ideas

Machesky studies the role of the actin cytoskeleton in cancer invasion and metastasis.


Cell biology in development


The kinetochore surveillance phosphatase PP2A-B56 dephosphorylates Knl1 to silence the spindle assembly checkpoint after all chromosomes have been correctly attached to microtubules.

The Greatwall kinase orthologue Mastl regulates timely activation of APC/C to allow meiosis I exit and suppresses PP2A activity and thereby allows the rapid rise of Cdk1 activity that is necessary for meiosis II entry in mouse oocytes.

Controlled Plk1 activity is required for gradual biochemical and structural maturation of centrioles, timely appendage assembly, and maintenance of proper cilia and centrosome number in dividing cells.

HIV protease converts procaspase 8 into Casp8p41, which binds and activates Bak to induce cell death in infected CD4 T cells.


Plk3 phosphorylates CtIP in G1 in a damage-inducible manner and is required with CtIP for the repair of complex double-strand breaks and regulation of resection-mediated end-joining pathways.

The RNA-binding protein Arrest occupies a novel intranuclear domain and directs flight muscle–specific patterns of alternative splicing in flies.

Cdc42 and the formins dDAAM and Diaphanous play pivotal roles in heart lumen formation through the spatiotemporal regulation of the actomyosin network.

Long-range signaling by Wingless in the Drosophila ovary requires the glypican Dally-like and is antagonized by Dally-like cleavage by the extracellular metalloproteinase Mmp2.

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