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The Drosophila RNA-binding protein Arrest (green) accumulates in the large nuclei of flight muscle founder cells, which are surrounded by Arrest-negative fusion-competent myoblasts. Nucleoli are labeled red, and nuclei are stained blue. Oas et al. show that Arrest resides in a novel nuclear domain called the B-body, where it colocalizes with the splicing factor Muscleblind. Following myoblast fusion, Arrest disperses in the nuclei and directs flight muscle-specific patterns of RNA splicing.
Image © 2014 Oas et al.
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Laura Machesky: Actin opens the way
Machesky studies the role of the actin cytoskeleton in cancer invasion and metastasis.
Review
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Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1
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Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila
The RNA-binding protein Arrest occupies a novel intranuclear domain and directs flight muscle–specific patterns of alternative splicing in flies.
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