In This Issue
People & Ideas
Dlg1 recruits LGN to the cortex of cells in the chick neuroepithelium and may provide instructive cues that drive planar spindle orientation.
Independent of the presence of rDNA repeats, topological constraints imposed by chromosome length and perinuclear attachment determine the efficiency with which sister chromatid intertwines are resolved by topoisomerase II and dynamic microtubules during anaphase.
In spite of global transcriptional inhibition, a decrease in HSF2 expression during mitosis allows for heat shock protein expression and protects cells against proteotoxicity.
By interacting with the collagen cargo receptor component cTAGE5, Sec12 concentrates at ER exit sites and generates the high levels of GTP-bound Sar1 necessary for export of collagen to the Golgi.
Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly
Cryo-EM and molecular dynamics simulations reveal unexpected flexibility in individual monomers and a stable interface between monomers in the spiral filaments formed by the ESCRT-III subunit Vps32/CHMP4B.
Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin–EB1 interactions
An interaction with the microtubule-binding protein EB1 enables the desmosomal protein desmoplakin to modify microtubule organization and dynamics near sites of cell–cell contact, subsequently regulating membrane localization of gap junction–forming connexins.
Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells into neural crest–like progenitors, which effectively form corneal endothelial monolayers that may eliminate the need for corneal transplantation.