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Cover Image
Cover Image
On the cover
As depicted in this 3D reconstruction of a Tetrahymena thermophila cell, secretory granules known as mucocysts (green) move through the cytoplasm to dock at the plasma membrane. Colored lines show the trajectories of the mobile mucocyst pool. Briguglio et al. reveal that the sortilin family of lysosomal sorting receptors deliver non-aggregated cargo proteins to the granules.
Image © 2013 Briguglio et al., and prepared with the help of Christine Labno.
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In This Issue
In Focus
Sortilins get a new delivery route
Lysosomal sorting receptors transport cargo to secretory granules in Tetrahymena.
People & Ideas
Review
Death of developing neurons: New insights and implications for connectivity
Architects in neural circuit design: Glia control neuron numbers and connectivity
Report
Individual pericentromeres display coordinated motion and stretching in the yeast spindle
During mitosis, cohesin and condensin cross-link pericentromeres of different chromosomes to coordinate centromere attachment sites.
Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains
Analysis of Odf2 deletion mutants reveals regions important for the formation of basal body transition fibers and centriole distal appendages and distinct regions required for basal feet and subdistal appendages.
Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis
Erlins are cholesterol-binding proteins that restrict the activation of SREBPs, key transcription factors for cholesterol and fatty acid biosynthetic genes, under conditions of cholesterol sufficiency.
Membrane domain organization of myelinated axons requires βII spectrin
The spectrin-based cytoskeleton functions as a barrier to restrict axonal proteins, such as juxtaparanodal K+ channels, to specific membrane domains.
A biosensor of local kinesin activity reveals roles of PKC and EB1 in KIF17 activation
A biosensor of local kinesin activity demonstrates that PKC and EB1 promote the activation of KIF17 on dynamic microtubules, where it contributes to microtubule stabilization in epithelia.
Article
The histone demethylase LSD1/KDM1A promotes the DNA damage response
The E3 ubiquitin ligase RNF168 recruits LSD1 to DNA damage sites, where it reduces histone methylation upstream of 53BP1 recruitment during the DNA damage response.
A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation
The dynamics of topoisomerase IIα binding to DNA and histones are important for successful mitosis and are regulated by a novel chromatin tether (ChT) domain in topoisomerase IIα.
Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring
Septin-dependent removal of membrane-associated Anillin and Sticky-dependent retention of Anillin are required for contractile ring stability and closure and for midbody ring formation.
The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules
The septins, but not midbody microtubules, are important for daughter cell cytoplasmic isolation and ESCRT-dependent midbody ring release during abscission.
Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5
Synaptic stimulation promotes proteasome-dependent degradation of p35, inactivation of Cdk5, and decreased phosphorylation of PP1, allowing PP1 to act in the induction of long-term depression.
Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena
The delivery of nonaggregated cargo proteins to Tetrahymena secretory granules requires receptors of the sortilin/VPS10 family, proteins classically associated with lysosome biogenesis.
