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Cover Image
Cover Image
On the cover
Schulze et al. reveal that the GTPase Dynamin 2 promotes the breakdown of lipid droplets by aiding the regeneration of lysosomes from autolysosomal compartments. In a hepatocyte lacking Dynamin 2, a membrane tubule protruding from a lipid droplet–containing autolysosome is abnormally long because it cannot be fragmented into new protolysosomes.
Image © 2013 Schulze et al.
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In This Issue
In Focus
Ensuring that yeast cells get their inheritance
A nucleoporin allows nuclear pore complexes access to daughter cell during mitosis.
People & Ideas
Daniel Colón-Ramos: Observing and making connections
Colón-Ramos studies neurodevelopment in C. elegans.
Review
Report
Inheritance of yeast nuclear pore complexes requires the Nsp1p subcomplex
The presence of members of an NPC subcomplex containing Nsp1p is required for NPC movement into a daughter yeast cell, allowing intact NPCs to bypass a filter that prevents movement of defective complexes.
Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype
Large, insoluble aggregates of a yeast prion protein are required for the prion phenotype, but soluble oligomers contain all the information necessary to transmit the prion conformation.
Microtubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements
Live imaging reveals that muscle microtubules are highly dynamic and build a durable network nucleated by static Golgi elements.
Article
The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1
A cytoplasmic pool of Nsp1 is targeted to the bud in a Myo2-dependent manner and is required for nuclear pore complex inheritance by daughter cells.
Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression
The Golgi protein RhoBTB3 in complex with CUL3 and RBX1 promotes Cyclin E ubiquitylation to allow its turnover during S phase and progression through the cell cycle.
Par1b links lumen polarity with LGN–NuMA positioning for distinct epithelial cell division phenotypes
Positioning of the mitotic spindle relative to the luminal domain in epithelial cells is determined by Par1b in a RhoA-mediated signaling pathway that involves the astral microtubule anchoring complex LGN–NuMA.
Extracellular cell wall β(1,3)glucan is required to couple septation to actomyosin ring contraction
β(1,3)glucan is critical for contractile ring positioning and for coupling septum synthesis to constriction of the contractile ring and plasma membrane extension during cytokinesis.
The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery
The V0 membrane domain of the V-ATPase reversibly dissociates from V1 at acidic intragranular pH and is necessary for normal exocytosis and synaptic transmission.
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
Atg38 provides a physical linkage between the Vps15–Vps34 and Atg14–Vps30 subcomplexes to facilitate PI3-kinase complex I formation.
Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes
Dynamin 2 is required for starvation-mediated breakdown of lipid droplets in hepatocytes by promoting vesiculation of autolysosomal tubules to release protolysosomes.
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress
FOXO1 orchestrates wound healing through the up-regulation of TGF-β1 and protection against oxidative stress, which together act to promote keratinocyte migration and decrease apoptosis.
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
The BMP signaling pathway promotes muscle growth and inhibits muscle wasting via SMAD1/5-dependent signaling.
Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures
Mathematical modeling and analysis of 3D epithelial structures indicate that epithelial growth can take place far from mechanical equilibrium, depending on cell–cell and cell–ECM contact, cell division, cortical contractility, and cell motility.
