Issues
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Cover Image
Cover Image
On the cover
Tetrad fluorescence microscopy shows a colony of wild-type fission yeast labeled for actin (green) and myosin regulatory light chain (red). Coffman et al. describe how two actin-nucleating formin proteins cooperate to assemble the actomyosin contractile ring during cytokinesis.
Image © 2013 Coffman et al.
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In This Issue
In Focus
Formin’ the cytokinetic ring
Study reveals how two formin proteins cooperate to assemble the contractile ring in fission yeast.
People & Ideas
Yohanns Bellaïche: Mastering multiscale morphology
Bellaïche uses physics and genetics to study tissue morphogenesis.
Review
Report
Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation
Patronin counteracts KLP10A activity at spindle poles to stabilize microtubule minus ends and induce spindle elongation during anaphase B.
Notch3 marks clonogenic mammary luminal progenitor cells in vivo
Notch3 expression characterizes a highly clonogenic and transiently quiescent luminal progenitor population in the mammary gland, the expansion of which is restricted by Notch3 receptor activity.
Article
Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin
The prolyl isomerase Pin1 stimulates the dephosphorylation of histone H1, stabilizing its binding to chromatin at transcriptionally active chromatin.
DNA methyltransferase-3–dependent nonrandom template segregation in differentiating embryonic stem cells
Asymmetrically dividing embryonic stem cells segregate the younger chromatid and de novo DNA methyltransferases into the differentiating cell and the older chromatid, with its epigenetic memory, into the self-renewing daughter cell.
Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset
MAD2L2 is rapidly degraded by APC/CCDC20 at the onset of anaphase, allowing release of sequestered CDH1 to activate the dephosphorylated APC/C.
The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis
Multiple formins cooperate during cytokinesis, but their functions in de novo actin assembly at the division site play the primary role in contractile ring assembly.
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
After bacterial invasion, ubiquitin is conjugated to host endosomal proteins and recognized by the autophagic machinery independent of LC3.
An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier
The ciliary permeability barrier is mechanistically distinct from other cellular diffusion barriers and allows soluble proteins under ∼100 kD in size to enter cilia in the absence of active transport.
Tools
Whole-genome screening identifies proteins localized to distinct nuclear bodies
A genome-wide microscopy screen identifies proteins localized to Cajal bodies, paraspeckles, and other known and previously uncharacterized nuclear subcompartments.
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