On the cover
Laporte et al. reveal that quiescent budding yeast form an array of microtubules (green) inside their nuclei (delineated by the nucleoporin Nup2, red). These microtubules reorganize the nucleus and promote cell survival and re-entry into the cell cycle. Yeast cell walls are labeled blue.
Image © 2013 Laporte et al.
See page 585.
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Atrophin suppresses Hedgehog signaling by interacting with the transcriptional effector CiR and recruiting the histone deacetylase Rpd3 to the dpp locus to repress its transcription.
A stable monopolar array of nuclear microtubules displaces the nucleolus and kinetochores during quiescence and is required for both quiescence survival and exit.
Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition
AGC kinase–mediated phosphorylation of the TOR kinase reduces its activity and results in physiologically significant changes in TOR signalling in both yeast and human cells.
The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK
Cingulin phosphorylation by AMPK promotes its binding to α-tubulin and is required for the association of planar apical microtubules with epithelial tight junctions.
Disulfide bonds introduced during or shortly after protein synthesis can occur without oxygen, whereas those introduced during post-translational folding or isomerization are oxygen dependent.
The crystal structure of a metastable, internal ligand-bound conformation of the αXβ2 integrin suggests it enables rapid equilibration between the bent-closed and extended-open conformational states.
Dysbindin activates RhoA–SRF and MEK1–ERK1 signaling pathways in cardiomyocytes to promote cardiac hypertrophy.
Local caspase activation at axonal branch points restricts arbor growth and synaptogenesis by interacting with Slit1a-Robo2 signaling in the central nervous system.
Lpd is an essential, evolutionary conserved regulator of the Scar/WAVE complex during cell migration in vivo.
Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models
Experimental analysis and computational modeling of epidermal wound closure in 3D suggests an important role for surrounding tissue in determining epithelial cell movement and fate.