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Cover Image
Cover Image
On the cover
Laporte et al. reveal that quiescent budding yeast form an array of microtubules (green) inside their nuclei (delineated by the nucleoporin Nup2, red). These microtubules reorganize the nucleus and promote cell survival and re-entry into the cell cycle. Yeast cell walls are labeled blue.
Image © 2013 Laporte et al.
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In This Issue
In Focus
Lamellipodin branches out
Lamellipodin functions as an essential, general regulator of cell migration via the Scar/WAVE complex.
People & Ideas
Marilyn Farquhar: From the beginning
Farquhar studies cellular secretion, endocytosis, and podocytes in the kidney.
Editorial
Feature
Review
Report
Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR
Atrophin suppresses Hedgehog signaling by interacting with the transcriptional effector CiR and recruiting the histone deacetylase Rpd3 to the dpp locus to repress its transcription.
An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence
A stable monopolar array of nuclear microtubules displaces the nucleolus and kinetochores during quiescence and is required for both quiescence survival and exit.
Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition
AGC kinase–mediated phosphorylation of the TOR kinase reduces its activity and results in physiologically significant changes in TOR signalling in both yeast and human cells.
The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK
Cingulin phosphorylation by AMPK promotes its binding to α-tubulin and is required for the association of planar apical microtubules with epithelial tight junctions.
Article
Two phases of disulfide bond formation have differing requirements for oxygen
Disulfide bonds introduced during or shortly after protein synthesis can occur without oxygen, whereas those introduced during post-translational folding or isomerization are oxygen dependent.
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2
The crystal structure of a metastable, internal ligand-bound conformation of the αXβ2 integrin suggests it enables rapid equilibration between the bent-closed and extended-open conformational states.
Dysbindin is a potent inducer of RhoA–SRF-mediated cardiomyocyte hypertrophy
Dysbindin activates RhoA–SRF and MEK1–ERK1 signaling pathways in cardiomyocytes to promote cardiac hypertrophy.
Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization
Local caspase activation at axonal branch points restricts arbor growth and synaptogenesis by interacting with Slit1a-Robo2 signaling in the central nervous system.
Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo
Lpd is an essential, evolutionary conserved regulator of the Scar/WAVE complex during cell migration in vivo.
Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models
Experimental analysis and computational modeling of epidermal wound closure in 3D suggests an important role for surrounding tissue in determining epithelial cell movement and fate.
