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Cover Image
Cover Image
On the cover
A transverse section through the midbrain of a chick embryo shows the effects of electroporation on the left side with a control morpholino and on the right side with a morpholino that blocks translation of the transcription factor Sip1. E-cadherin (red) is up-regulated in the absence of Sip1, preventing neural crest cells from detaching from each other and completing their epithelial-to-mesenchymal transition. Both morpholinos are labeled green.
Image © 2013 Rogers et al.
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In This Issue
In Focus
Silent RNAs express themselves
Study finds that RNA molecules housed in cytoplasmic granules are active.
People & Ideas
Review
Report
The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery
Telomere positioning near the nuclear envelope during Caenorhabditis elegans development requires the nuclear envelope protein SUN-1, the Shelterin component POT-1, and the SUMO ligase GEI-17.
The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules
Fus regulates translation of APC-associated RNAs at cell protrusions and misdirects their translation in cytoplasmic granules upon overexpression or expression of ALS–linked Fus mutants.
Loss of centrioles causes chromosomal instability in vertebrate somatic cells
Centrosomes establish a mitotic spindle geometry that facilitates correct kinetochore–microtubule attachments, contributing to the fidelity of chromosome segregation.
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
A subset of phagosomes in human macrophages and dendritic cells that is marked by a coat of autophagy-related proteins maintains phagocytosed antigens for prolonged presentation on MHC class II molecules.
Article
β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications
Multiple cis-elements surrounding the β-globin gene locus combine to target this locus to the nuclear periphery through at least two different epigenetic marks.
CP110 exhibits novel regulatory activities during centriole assembly in Drosophila
Although loss of CP110 is tolerated in Drosophila, CP110 is important for limiting centriole length, limiting centriolar microtubule length, and suppressing centriole overduplication when duplication proteins are overexpressed.
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts
Fusion of ER membranes by atlastin and interaction of ER with growing microtubule ends and dynein cooperate to generate distinct ER morphologies during the cell cycle.
FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions
The barbed-end actin capping protein FSGS3/CD2AP localizes to apical adherens junctions in polarized cells, where it promotes adhesive strength and barrier function.
Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT
Sip1 promotes the mesenchymalization stage of the neural crest epithelial-to-mesenchymal transition by inducing a transcriptional switch in cells from expression of E-cadherin to N-cadherin.
Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans
Liprin-α/SYD-2 activity promotes the polymerization of electron-dense projections in the presynaptic active zone through increased recruitment of ELKS-1/ELKS.
