Issues
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Cover Image
Cover Image
On the cover
Microtubules (green) in a two-cell stage mouse embryo self-assemble into a mitotic spindle from multiple microtubule-organizing centers (red), a mechanism similar to meiotic spindle formation. Courtois et al. reveal that cells gradually transition from meiosis to mitosis over the first few divisions of embryonic development. Chromosomes in both the cells and polar body are stained blue.
Image © 2012 Courtois et al.
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In This Issue
In Focus
Outgrowing meiosis
Study finds that a fertilized egg doesn't immediately start dividing mitotically.
People & Ideas
Barry Thompson: The delicate choreography in growing epithelia
Thompson is studying how epithelial polarity informs tissue growth and form.
Editorial
Review
Report
Loss of ATM kinase activity leads to embryonic lethality in mice
In contrast to ATM-null mice, mice expressing a kinase-dead ATM variant exhibit embryonic lethality, associated with greater deficiency in homologous recombination.
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice
Expression of a kinase-deficient ATM protein leads to severe genomic instability and embryonic lethality.
Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy
Cryoelectron microscopy reveals conformational changes at the contacts between tubulins between GMPCPP and GDP-taxol microtubules.
All three components of the neuronal SNARE complex contribute to secretory vesicle docking
Docking of large dense-core vesicles is reduced by cleavage of any of the neuronal SNARE complex proteins: synaptobrevin, syntaxin, or SNAP-25.
The tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Asymmetric stem cell divisions controlled by Apc in the intestinal crypt result in regulated, anisotropic movement of daughter cells away from the niche.
Article
Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport
Instead of the structural nuclear lamina seen in animals, fungi use motor-driven motility of nuclear pore complexes to ensure chromosome organization and efficient nuclear transport.
The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development
The transition from a meiotic-like spindle formation characterized by lack of centrioles to a typical mitotic spindle occurs gradually in embryos during the preimplantation stage.
ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load
Inactivating ADP ribosylation of the ER chaperone BiP is a rapidly reversible mechanism for buffering acute changes in unfolded protein load.
Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
The Hsp70 system recruits ClpB/Hsp104 to the surface of stress-induced protein aggregates and prion fibrils.
Seg1 controls eisosome assembly and shape
Seg1 establishes a platform for the assembly of eisosomes and is important for determining their length.
Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane
Agrin regulates acetylcholine receptors at the neuromuscular junction by locally stabilizing microtubules through the plus end tracking proteins CLASP2 and CLIP-170.
HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly
The RNA helicase DDX6 promotes HIV-1 assembly in a co-opted cellular complex containing P body proteins and ABCE1.
Tools
Virtual nanoscopy: Generation of ultra-large high resolution electron microscopy maps
Using transmission electron microscopy, automated data collection, and image stitching, biological specimens as large as one square millimeter can be ultrastructurally mapped at nanometer resolution.
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