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    Microtubules (green) in a two-cell stage mouse embryo self-assemble into a mitotic spindle from multiple microtubule-organizing centers (red), a mechanism similar to meiotic spindle formation. Courtois et al. reveal that cells gradually transition from meiosis to mitosis over the first few divisions of embryonic development. Chromosomes in both the cells and polar body are stained blue.
    Image © 2012 Courtois et al.
    See page 357.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study finds that a fertilized egg doesn't immediately start dividing mitotically.

People & Ideas

Thompson is studying how epithelial polarity informs tissue growth and form.




In contrast to ATM-null mice, mice expressing a kinase-dead ATM variant exhibit embryonic lethality, associated with greater deficiency in homologous recombination.

Expression of a kinase-deficient ATM protein leads to severe genomic instability and embryonic lethality.

Cryoelectron microscopy reveals conformational changes at the contacts between tubulins between GMPCPP and GDP-taxol microtubules.

Docking of large dense-core vesicles is reduced by cleavage of any of the neuronal SNARE complex proteins: synaptobrevin, syntaxin, or SNAP-25.

Asymmetric stem cell divisions controlled by Apc in the intestinal crypt result in regulated, anisotropic movement of daughter cells away from the niche.


Instead of the structural nuclear lamina seen in animals, fungi use motor-driven motility of nuclear pore complexes to ensure chromosome organization and efficient nuclear transport.

The transition from a meiotic-like spindle formation characterized by lack of centrioles to a typical mitotic spindle occurs gradually in embryos during the preimplantation stage.

Inactivating ADP ribosylation of the ER chaperone BiP is a rapidly reversible mechanism for buffering acute changes in unfolded protein load.

The Hsp70 system recruits ClpB/Hsp104 to the surface of stress-induced protein aggregates and prion fibrils.

Seg1 establishes a platform for the assembly of eisosomes and is important for determining their length.

Agrin regulates acetylcholine receptors at the neuromuscular junction by locally stabilizing microtubules through the plus end tracking proteins CLASP2 and CLIP-170.

The RNA helicase DDX6 promotes HIV-1 assembly in a co-opted cellular complex containing P body proteins and ABCE1.


Using transmission electron microscopy, automated data collection, and image stitching, biological specimens as large as one square millimeter can be ultrastructurally mapped at nanometer resolution.

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