In This Issue
People & Ideas
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis
The mammalian meiosis-specific KASH protein KASH5 connects the telomere-associated SUN1 protein to the cytoplasmic force–generating mechanism involved in meiotic chromosome movement.
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores
Repo-Man and Sds22 counteract Aurora B phosphorylation of Dsn1 and thus regulate the kinetochore–microtubule interface during anaphase.
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc
ERK-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity independently of its effect on proliferation.
Relatively stable microvillar components are linked in vivo by the scaffolding protein EBP50 in spite of its surprisingly high turnover rate.
The state of CENP-E–dependent BubR1 autophosphorylation in response to spindle microtubule capture regulates kinetochore function and accurate chromosome segregation.
Atg9-containing vesicles assemble to the preautophagosomal structure and eventually are incorporated into the autophagosomal outer membrane.
PI(3,5)P2 is directly linked to generation and remodeling of the cortical actin array by formin during polarized cell growth in plants.
Synaptic activity–dependent remodeling of the glutamate receptor scaffold complex generates a negative feedback loop that limits further NMDA receptor activation.