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Cover Image
Cover Image
On the cover
A photoactivatable version of the microvillar scaffold protein EBP50 (green) is labeled in a subset of microvilli (red) on the apical surface of epithelial cells. Garbett and Bretscher find that EBP50 is surprisingly dynamic inside microvilli and that its turnover is regulated by its PDZ domains.
Image © 2012 Garbett and Bretscher.
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In This Issue
In Focus
PI(3,5)P2 sows the seeds of plant growth
Phospholipid directs polarized growth by targeting actin-polymerizing formins to the cortex of plant cells.
People & Ideas
Karen Vousden: Getting the big picture on p53
Vousden studies the activities and regulation of the tumor suppressor p53.
Review
Report
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis
The mammalian meiosis-specific KASH protein KASH5 connects the telomere-associated SUN1 protein to the cytoplasmic force–generating mechanism involved in meiotic chromosome movement.
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores
Repo-Man and Sds22 counteract Aurora B phosphorylation of Dsn1 and thus regulate the kinetochore–microtubule interface during anaphase.
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc
ERK-mediated up-regulation of c-myc by K-Ras or B-Raf oncogenes disrupts the establishment of apical/basolateral polarity independently of its effect on proliferation.
PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli
Relatively stable microvillar components are linked in vivo by the scaffolding protein EBP50 in spite of its surprisingly high turnover rate.
Article
CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint
The state of CENP-E–dependent BubR1 autophosphorylation in response to spindle microtubule capture regulates kinetochore function and accurate chromosome segregation.
Atg9 vesicles are an important membrane source during early steps of autophagosome formation
Atg9-containing vesicles assemble to the preautophagosomal structure and eventually are incorporated into the autophagosomal outer membrane.
Class II formin targeting to the cell cortex by binding PI(3,5)P2 is essential for polarized growth
PI(3,5)P2 is directly linked to generation and remodeling of the cortical actin array by formin during polarized cell growth in plants.
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
Synaptic activity–dependent remodeling of the glutamate receptor scaffold complex generates a negative feedback loop that limits further NMDA receptor activation.
