In This Issue
People & Ideas
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
In contrast to what has been reported previously, endo-lysosomal dysfunction in presenilin-deficient cells does not arise from improper glycosylation of the lysosomal V-ATPase but rather from defective lysosomal calcium homeostasis.
The planar cell polarity effector Fuz is required for normal particle dynamics of the intraflagellar transport system, specifically in the retrograde transport of proteins.
Myo1c directly interacts with G-actin and is important for its transport to the leading edge during endothelial cell migration.
Drosophila Evi5 is a Rab-GAP that acts on the membrane-trafficking mediator Rab11 to promote guidance receptor polarization during border cell migration.
Vacuole- and mitochondria-specific cargo adaptors compete for an overlapping binding site on Myo2 to determine the inheritance of these organelles during budding.
Two actin-assembling formins, CYK-1 and FHOD-1, are important for muscle cell growth and maintenance of the contractile lattice in striated muscle cells.
Apoptosis during epithelial lumen formation is mediated by hypoxia-induced expression of the proapoptotic protein Bnip3, which is promoted by AIF-mediated reactive oxygen species production and HIF-2α stabilization.
At the tip of flagella, an array of LC8 dimers binds to the spoke protein RSP3 in radial spoke precursors, triggering phosphorylation, stalk base formation, and axoneme targeting.
c-Jun in Schwann cells promotes the expression of Ret ligands GDNF and Artemin, which leads to enhanced motoneuron survival and axonal regeneration after injury.