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Cover Image
Cover Image
On the cover
The formin CYK-1 (green) localizes to the Z lines of sarcomeres in C. elegans body wall muscles. Mi-Mi et al. demonstrate that CYK-1 and a second formin called FHOD-1 assemble actin filaments into the contractile lattice of these striated muscle cells. Nuclei are stained blue. Image © 2012 Mi-Mi et al.
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In This Issue
In Focus
Schwann cells aid regeneration project
Study reveals how the expression of c-Jun in Schwann cells helps restore damaged nerves.
People & Ideas
Jiri Lukas: Visualizing genome integrity maintenance
Lukas studies how cells detect and deal with DNA damage throughout the cell cycle.
Review
Report
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
In contrast to what has been reported previously, endo-lysosomal dysfunction in presenilin-deficient cells does not arise from improper glycosylation of the lysosomal V-ATPase but rather from defective lysosomal calcium homeostasis.
Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz
The planar cell polarity effector Fuz is required for normal particle dynamics of the intraflagellar transport system, specifically in the retrograde transport of proteins.
Myo1c facilitates G-actin transport to the leading edge of migrating endothelial cells
Myo1c directly interacts with G-actin and is important for its transport to the leading edge during endothelial cell migration.
Evi5 promotes collective cell migration through its Rab-GAP activity
Drosophila Evi5 is a Rab-GAP that acts on the membrane-trafficking mediator Rab11 to promote guidance receptor polarization during border cell migration.
Article
Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes
Vacuole- and mitochondria-specific cargo adaptors compete for an overlapping binding site on Myo2 to determine the inheritance of these organelles during budding.
Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans
Two actin-assembling formins, CYK-1 and FHOD-1, are important for muscle cell growth and maintenance of the contractile lattice in striated muscle cells.
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis
Apoptosis during epithelial lumen formation is mediated by hypoxia-induced expression of the proapoptotic protein Bnip3, which is promoted by AIF-mediated reactive oxygen species production and HIF-2α stabilization.
The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly
At the tip of flagella, an array of LC8 dimers binds to the spoke protein RSP3 in radial spoke precursors, triggering phosphorylation, stalk base formation, and axoneme targeting.
c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling
c-Jun in Schwann cells promotes the expression of Ret ligands GDNF and Artemin, which leads to enhanced motoneuron survival and axonal regeneration after injury.
