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Inactivating clathrin in S phase reveals the protein's involvement in centrosome maturation.

People & Ideas

Nicklas performed innovative studies on the forces that drive cell division.



Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore–microtubule attachments and subsequently silencing the spindle checkpoint.

In the absence of SCAR, Dictyostelium WASP is relocalized from coated pits to the leading edge of the cell and activated to drive pseudopod formation.


Studies of EBV replication origins demonstrate an excess of pre-replication complexes that are formed at flexible MNase-sensitive sites in the genome.

Localization of the miRNA-induced silencing complex to GW/P bodies by GW220/TNGW1 may regulate the fate of target mRNAs.

Rab10 activation promotes GLUT4 storage vesicle recruitment to the plasma membrane in response to insulin and coordinates with myosin-Va to mediate vesicle fusion.

TLR9 localizes to a novel intracellular compartment called the T granule to promote immune signaling by platelets.

During muscle atrophy induced by fasting, Trim32 promotes degradation of desmin cytoskeleton, which is linked to the loss of Z-bands and thin filaments.

Clathrin inactivation during S phase destabilizes the microtubule-binding protein ch-TOG, affecting its centrosomal localization and centrosome integrity during early mitosis.

Control of cell cycle progression relies on unique regulation of centrosomal cAMP/PKA signals through PKA and PDE4D3 interaction with the A kinase anchoring protein AKAP9.

The Hsp70–Hsp110 chaperone complex antagonizes Cin8 plus-end motility and prevents premature spindle elongation in S phase.

The α(1-3)glucan synthase Ags1 is essential for both secondary septum formation and the primary septum structural strength needed to counter cell turgor pressure during cell separation.

Mena binds to the cytoplasmic tail of α5 integrin and modulates key α5β1 integrin functions in adhesion, motility, and fibrillogenesis.

Epithelial junction formation and morphogenesis requires the GTPase-activating protein SH3BP1 and the F-actin–capping protein CapZ to guide Cdc42 signaling and cytoskeletal dynamics.

Wnt-11/frizzled-7 reduces the lateral clustering of C-cadherin by capturing the protocadherin PAPC and C-cadherin into distinct adhesion-modulating complexes.

A gradient of PI(4,5)P2 formed by phospholipid synthesis, diffusion, and regulated turnover is crucial for filamentous growth.

Assembly of the trilaminar eggshell and development of the permeability barrier after fertilization in C. elegans are distinct in their timing and mechanism.


A novel split kinesin assay identifies three Kinesin-3 family members that specifically interact with dendritic vesicle populations in neurons.

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