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Aurora A, which is known to be activated by autophosphorylation at Thr288, is also locally activated during centrosomal maturation by nucleophosmin-mediated phosphorylation at Ser89.
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell
Autophagy genes are not only essential for exposing the engulfment signal on apoptotic cells but also function in phagocytes to promote apoptotic cell removal.
After fertilization, the metalloendoprotease ovastacin is released by cortical granule exocytosis and cleaves the zona pellucida glycoprotein ZP2, an essential step to block sperm binding to an already fertilized egg.
A new method for visualizing translation in cells via standard immunofluorescence microscopy provides evidence for translation in the nucleoplasm and nucleolus.
Microtubule nucleation sites in yeast consist of a ring of γ-tubulin small complexes and a slight excess of uncomplexed γ-tubulin.
A signaling module known to organize the actin cytoskeleton during neuronal guidance also instructs synaptic vesicle clustering during synapse assembly.
The strength of a signal generated by membrane growth could indicate when sufficient cell growth has occurred for mitotic entry.
Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibroblasts to align with an external chemotactic gradient.
Rapid signaling and structural adaptations to the actin cytoskeleton enable leukocytes to stabilize α4 integrin–mediated adhesion and resist detachment from inflamed endothelium.
A multivariate proteomics approach identified numerous new clathrin-coated vesicle proteins as well as the first AP-4 accessory protein, and also revealed how auxilin depletion causes mitotic arrest through sequestration of spindle proteins in clathrin cages.