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    Cranial mesenchyme cells are pictured migrating out of an explant dissected from a wild-type mouse embryo. Sarkar and Zohn show that cell motility is enhanced in the absence of the ubiquitin ligase Hectd1 due to excessive secretion of one of its target proteins, Hsp90. This may explain the abnormal cranial mesenchyme organization and neural tube closure defects seen in Hectd1-deficient embryos.
    Image courtesy of Anjali Sarkar.
    See page 789.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study suggests that cranial mesenchyme cells must limit Hsp90 secretion during development.

People & Ideas

Biggins studies kinetochores and the mitotic checkpoint.



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Hectd1 is a ubiquitin ligase that targets the chaperone Hsp90. In the absence of Hectd1 ubiquitin ligase activity, Hsp90 secretion is elevated, resulting in abnormal behavior of cranial mesenchyme cells.


Proximity-dependent biotin identification (BioID) is a new approach making use of biotin ligase fusion proteins for the identification of both interacting and neighboring proteins in their native cellular environment.

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