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JCB65: Methods

In the first collection celebrating our 65th anniversary , we revisit classic methods that shaped cell biological research, including a fundamentally important technique for electron microscopy that has proved to be critical for all areas of cell biology, the development of laser scanning confocal imaging, the description of the TUNEL assay and early uses of the Lac O/Lac I system to visualize chromatin structure and dynamics. The collection highlights recent techniques refining the toolboxes of today’s cell biologists, such as the now-common BioID method probing protein–protein interactions and the introduction of nanobodies as an alternative to anti–immunoglobulin G secondary antibodies. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or e-mail us at jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Reynolds, 1963.

Special Collection Image
Tools
Yu Chen; Yang Zhang; Yuchuan Wang; Liguo Zhang; Eva K. Brinkman; Stephen A. Adam; Robert Goldman; Bas van Steensel; Jian Ma; Andrew S. Belmont
DOI: 10.1083/jcb.201807108
Tools
Tino Pleiner; Mark Bates; Dirk Görlich
DOI: 10.1083/jcb.201709115
Tools
Thomas G. McWilliams; Alan R. Prescott; George F.G. Allen; Jevgenia Tamjar; Michael J. Munson; Calum Thomson; Miratul M.K. Muqit; Ian G. Ganley
DOI: 10.1083/jcb.201603039
Tools
Kyle J. Roux; Dae In Kim; Manfred Raida; Brian Burke
DOI: 10.1083/jcb.201112098
Articles
Philip A. Wigge; Ole N. Jensen; Simon Holmes; Sylvie Souès; Matthias Mann; John V. Kilmartin
DOI: 10.1083/jcb.141.4.967
Article
C C Robinett; A Straight; G Li; C Willhelm; G Sudlow; A Murray; A S Belmont
DOI: 10.1083/jcb.135.6.1685
Article
T A Vida; S D Emr
DOI: 10.1083/jcb.128.5.779
Article
Y A Lazebnik; S Cole; C A Cooke; W G Nelson; W C Earnshaw
DOI: 10.1083/jcb.123.1.7
Article
Y Gavrieli; Y Sherman; S A Ben-Sasson
DOI: 10.1083/jcb.119.3.493
Article
J G White; W B Amos; M Fordham
DOI: 10.1083/jcb.105.1.41
Article
P Greenspan; E P Mayer; S D Fowler
DOI: 10.1083/jcb.100.3.965
Article
J V Kilmartin; B Wright; C Milstein
DOI: 10.1083/jcb.93.3.576
Article
Y Fujiki; A L Hubbard; S Fowler; P B Lazarow
DOI: 10.1083/jcb.93.1.97
Article
D Louvard; H Reggio; G Warren
DOI: 10.1083/jcb.92.1.92
Article
L V Johnson; M L Walsh; B J Bockus; L B Chen
DOI: 10.1083/jcb.88.3.526
Article
J E Heuser; T S Reese; M J Dennis; Y Jan; L Jan; L Evans
DOI: 10.1083/jcb.81.2.275
Article
N Dwyer; G Blobel
DOI: 10.1083/jcb.70.3.581
Article
Tom Elsdale; Jonathan Bard
DOI: 10.1083/jcb.54.3.626
Article
M. N. Berry; D. S. Friend
DOI: 10.1083/jcb.43.3.506
Article
Ewald R. Weibel; Willy Stäubli; Hans Rudolf Gnägi; Felix A. Hess
DOI: 10.1083/jcb.42.1.68
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