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    A hair follicle (stained for E-cadherin, green) from a mouse whose skin lacks Runx1 in its mesenchymal layer shows ectopic expression of the transcription factor Lef1 (red) in the hair follicle stem cell compartment. Osorio et al. reveal that mesenchymal Runx1 suppresses epithelial Lef1 expression during embryonic development to guide the specification and maintenance of adult hair follicle stem cells. Image courtesy of Karen Osorio.
    See page 235.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Researchers detail how kinetochores respond to force from spindle.

People & Ideas

Walter studies how proteins are targeted to the endoplasmic reticulum and how cells deal with ER stress.

Review

Report

The histone deacetylase HDAC4 associates with the nuclear pore complex component Nup155 to modulate gene expression during cardiomyocyte hypertrophy.

Mouse NEAT1 is required for paraspeckle formation in a subset of cells but is not essential for animal health and viability.

Mutations that impair activity of the ER stress response kinase Ire1 inhibit resolution of the unfolded protein response (see also a related paper by Rubio et al. in this issue).

The low-density lipoprotein receptor (LDLR) doesn’t directly bind AP-1B; however, it relies on this clathrin adaptor for basolateral exocytosis. Identification of the autosomal recessive hypercholesterolemia protein (ARH) as a link between LDLR and AP-1B explains this apparent discrepancy and provides a model for how other endocytic proteins may contribute to endosomal recycling.

In response to growth factor stimulation, integrins transit through recycling endosomes to reach newly forming focal adhesions at the cell’s leading edge.

Rings lost fulfills a novel function in Drosophila development for a ubiquitin receptor as an essential mediator of ring canal growth during oogenesis.

Article

p150CAF-1-mediated recruitment of HP1α to DNA is essential for efficient assembly of DNA damage response complexes and subsequent homologous recombination repair.

53BP1-OPT domains, nuclear bodies that arise in G1 cells at sites of DNA damage induced by incomplete DNA replication, preferentially localize to chromosomal common fragile sites.

The ER–inner nuclear membrane trafficking of 15 integral membrane proteins followed by FRAP shows distinct ATP- and Ran-dependent translocation mechanisms.

The N and C termini of CENP-T undergo tension-dependent separation, suggesting that CENP-T elongation is responsible for changes in the shape of the inner kinetochore.

Knockdown or mislocalization of LGN complex components disrupts the stereotypic biphasic spindle movements regulating planar cell division and neuroepithelial structure in chick embryos.

In contrast to their sequential roles in midzone assembly, the CPC and centralspindlin act through independent mechanisms to regulate contractile ring assembly.

Uncoupling of Ire1’s RNAse and kinase activities reveals that its auto-phosphorylation is important for resolution of the unfolded protein response. (See also a related paper by Chawla et al. in this issue).

SNARE complex assembly and mobilization of GLUT4 vesicles is coordinated through direct targeting of Munc18c by the insulin receptor tyrosine kinase.

Association of Nwk with SNX16 promotes down-regulation of synaptic growth signaling at the interface between early and recycling endosomes.

The NHERF1-ERM-actin network comprises a selective retention matrix that prevents interacting membrane proteins from entering the ciliary membrane.

Runx1 controls timing of adult HSFC and short-term progenitor emergence in the embryonic epithelium and HFSC differentiation and long-term skin integrity in embryonic mesenchyme.

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