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Cover Image
Cover Image
On the cover
Casein kinase 1δ (green) localizes to the centrosome (red), where it promotes neurite extension in response to Wnt-3a. Image courtesy of Yoshimi Endo Greer. See page 993. - PDF Icon PDF LinkTable of Contents
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In This Issue
In Focus
Cadherins trade bonds
Study describes how adhesion molecules rearrange their interactions to exit cell junctions.
People & Ideas
Pascale Cossart: The ins and outs of Listeria
Cossart studies how Listeria monocytogenes manipulates the biology of its host cells.
Review
Report
A CHOP-regulated microRNA controls rhodopsin expression
ER stress induces expression of miR-708, which suppresses the production of rhodopsin to prevent ER overloading in retinal epithelial cells.
PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans
PGL proteins act as scaffolds that recruit RNPs during C. elegans germ granule formation.
P granules extend the nuclear pore complex environment in the C. elegans germ line
Like the nuclear pore complex, FG repeat–containing P-granule proteins interact to help establish a size-exclusion barrier.
Metabolic status rather than cell cycle signals control quiescence entry and exit
The use of new candidate markers for yeast quiescence reveals that quiescence entry and exit primarily rely on cellular metabolic status and can be uncoupled from the cell cycle.
The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
Kinastrin is identified as a major interacting partner for astrin in mitotic cells, and is required for astrin targeting to microtubule plus ends.
A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission
In addition to its function as an initiator of DNA replication, vertebrate Orc6 is also required for the final step of cytokinesis.
Article
Phosphatidylserine is a critical modulator for Akt activation
Association of Akt with phosphatidylserine enhances binding to PIP3, inducing conformational changes in Akt that promote its phosphorylation-mediated activation.
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a–dependent neurite outgrowth
Centrosomal localization of kinase-active CK1δ is required for neurite outgrowth in response to Wnt-3a.
Assembly and architecture of precursor nodes during fission yeast cytokinesis
Mapping of fission yeast precursor node interaction modules and assembly reveals important steps in contractile ring assembly.
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
Eight proteins, defects in which are associated with Meckel-Gruber syndrome and nephronophthisis ciliopathies, work together as two functional modules at the transition zone to establish basal body/transition zone connections with the membrane and barricade entry of non-ciliary components into this organelle.
The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets
Pah1p promotes lipid droplet assembly independent of its role in triacylglycerol synthesis.
Control of bone formation by the serpentine receptor Frizzled-9
Fzd9, induced upon osteoblast differentiation, is required for bone matrix mineralization in primary osteoblasts.
Cadherin exits the junction by switching its adhesive bond
Intercellular traction forces or lateral alignment of cadherin molecules can influence adherens junction dynamics by altering the cadherin dimerization interface.
