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In Focus

The tumor suppressor functions outside the nucleus to regulate cell adhesion and migration.

People & Ideas

Blasco is at the forefront of research on the function of telomeres in cancer and aging.



Drosophila fob encodes a homolog of the Vps16 HOPS complex subunit, required for phagosome maturation and digestion of engulfed pathogens.

RIP1 is a component of a TRAF2 complex, required for caspase-8 activation and tumor cell killing in response to ligand binding of CD40.


Continued association of RPA with sites of incomplete nucleotide excision repair averts further incision events until repair is completed.

Arrays of Sir3 binding sites at telomeres are sufficient to promote long-range trans-telomere interactions.

Binding of the N terminus of Ndel1 to dynein facilitates microtubule self-organization in Ran-induced asters.

Complexes containing tafazzin, which remodels newly synthesized cardiolipin, are destabilized by mutations associated with Barth syndrome.

A single-molecule tracking technique coupled with mathematical modeling was developed for fully determining the dynamic monomer–dimer equilibrium of molecules in or on the plasma membrane, which will provide a framework for understanding signal transduction pathways initiated and regulated by dynamic dimers of membrane-localized receptors.

FGF signaling in neurons is regulated by Survival Motor Neuron, a component of a complex that regulates snRNP biogenesis and FGF receptor expression.

BRCA1 interacts with ERM proteins at leading edges and focal adhesion sites and modulates motility via its ubiquitin ligase activity.

The PDGF/VEGF-related receptor and the EGF receptor control the direction of collective cell migration by regulating the persistence and productivity of protrusions.

Par1b regulates cell–ECM signaling and dictates epithelial lumenal organization by targeting IRSp53, a Rho GTPase adaptor and scaffolding protein.

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