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Cover Image
Cover Image
On the cover
Circulating tumor cells from the peripheral blood of a prostate cancer patient are captured on a Herringbone-Chip. Yu et al. review methods of isolating and characterizing these rare metastatic precursors. Image courtesy of Shannon Stott.
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In This Issue
In Focus
BRCA1 on the move
The tumor suppressor functions outside the nucleus to regulate cell adhesion and migration.
People & Ideas
María Blasco: Keeping a cap on cancer and aging
Blasco is at the forefront of research on the function of telomeres in cancer and aging.
Review
Report
The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila
Drosophila fob encodes a homolog of the Vps16 HOPS complex subunit, required for phagosome maturation and digestion of engulfed pathogens.
The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas
RIP1 is a component of a TRAF2 complex, required for caspase-8 activation and tumor cell killing in response to ligand binding of CD40.
Article
Replication protein A safeguards genome integrity by controlling NER incision events
Continued association of RPA with sites of incomplete nucleotide excision repair averts further incision events until repair is completed.
Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast
Arrays of Sir3 binding sites at telomeres are sufficient to promote long-range trans-telomere interactions.
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein
Binding of the N terminus of Ndel1 to dynein facilitates microtubule self-organization in Ran-induced asters.
Barth syndrome mutations that cause tafazzin complex lability
Complexes containing tafazzin, which remodels newly synthesized cardiolipin, are destabilized by mutations associated with Barth syndrome.
Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging
A single-molecule tracking technique coupled with mathematical modeling was developed for fully determining the dynamic monomer–dimer equilibrium of molecules in or on the plasma membrane, which will provide a framework for understanding signal transduction pathways initiated and regulated by dynamic dimers of membrane-localized receptors.
Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling
FGF signaling in neurons is regulated by Survival Motor Neuron, a component of a complex that regulates snRNP biogenesis and FGF receptor expression.
A novel role for BRCA1 in regulating breast cancer cell spreading and motility
BRCA1 interacts with ERM proteins at leading edges and focal adhesion sites and modulates motility via its ubiquitin ligase activity.
Cell behaviors regulated by guidance cues in collective migration of border cells
The PDGF/VEGF-related receptor and the EGF receptor control the direction of collective cell migration by regulating the persistence and productivity of protrusions.
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell–ECM signaling
Par1b regulates cell–ECM signaling and dictates epithelial lumenal organization by targeting IRSp53, a Rho GTPase adaptor and scaffolding protein.
