On the cover
A cross section of a mouse sciatic nerve shows a Schwann cell wrapping a neuronal axon in a myelin sheath. Novak et al. demonstrate that the actin regulator N-WASP is required for this process. Image courtesy of Nurit Novak.
See page 243.
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In This Issue
People & Ideas
Phosphorylation of Polη links DNA damage–induced checkpoint activation and translesion synthesis in mammalian cells.
A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination
While ESCRT-0 is ubiquitinated by the Rsp5 E3 ligase, loss of Rsp5 does not disrupt monoubiquitin-dependent sorting into multivesicular bodies.
Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repair
The single-strand DNA–binding protein RPA promotes 5′-strand resection to generate 3′ single strands for homology-dependent DNA double-strand repair.
The meiosis-specific kleisin cohesin subunit, RAD21L, may participate in synapsis initiation and crossover recombination between homologous chromosomes.
RNA polymerase I–specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle
The Pol I subunits Rpa34 and Rpa49, required for elongation and 35S rRNA production, promote clustering of neighboring Pol I complexes to enhance the rRNA gene transcription cycle.
Formation of actin-rich structures along the lateral borders of subperineurial glial cells are induced and maintained by the G protein–coupled receptor Moody.
Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis
The compliance and dimensionality of the ECM regulate distinct changes in microtubule growth speed and growth persistence.
Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
Upon loss of a binding partner in apposed tissue, the homophilic cell adhesion protein Echinoid adopts a planar polarized localization, which promotes the planar polarized localization of the planar cell polarity protein Bazooka/Par-3 and targets actomyosin cable assembly to the epidermal leading edge, thus establishing the migration direction of the developing epidermis.
The dystrophin protein complex, an important regulator of muscle membrane integrity, also maintains neural organization through interactions with the L1CAM family member SAX-7.