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Cover Image
Cover Image
On the cover
A cross section of a mouse sciatic nerve shows a Schwann cell wrapping a neuronal axon in a myelin sheath. Novak et al. demonstrate that the actin regulator N-WASP is required for this process. Image courtesy of Nurit Novak.
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In This Issue
In Focus
Helping the embryo find closure
Loss of protein from neighbors tells migrating cells they are in the vanguard.
People & Ideas
Matthew Welch: The many branches of actin regulation
Welch investigates how host cells and pathogens initiate actin polymerization.
Review
Report
ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
Phosphorylation of Polη links DNA damage–induced checkpoint activation and translesion synthesis in mammalian cells.
A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination
While ESCRT-0 is ubiquitinated by the Rsp5 E3 ligase, loss of Rsp5 does not disrupt monoubiquitin-dependent sorting into multivesicular bodies.
N-WASP is required for membrane wrapping and myelination by Schwann cells
N-WASP–deficient Schwann cells sort and ensheath axons but arrest at the promyelinating stage.
Article
Replication protein A promotes 5′→3′ end processing during homology-dependent DNA double-strand break repair
The single-strand DNA–binding protein RPA promotes 5′-strand resection to generate 3′ single strands for homology-dependent DNA double-strand repair.
RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis
The meiosis-specific kleisin cohesin subunit, RAD21L, may participate in synapsis initiation and crossover recombination between homologous chromosomes.
RNA polymerase I–specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle
The Pol I subunits Rpa34 and Rpa49, required for elongation and 35S rRNA production, promote clustering of neighboring Pol I complexes to enhance the rRNA gene transcription cycle.
Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast
The ubiquitin hydrolase activating factor Bro1 enhances ESCRT-III stability by inhibiting Vps4-mediated disassembly.
The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures
Formation of actin-rich structures along the lateral borders of subperineurial glial cells are induced and maintained by the G protein–coupled receptor Moody.
Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis
The compliance and dimensionality of the ECM regulate distinct changes in microtubule growth speed and growth persistence.
Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
Upon loss of a binding partner in apposed tissue, the homophilic cell adhesion protein Echinoid adopts a planar polarized localization, which promotes the planar polarized localization of the planar cell polarity protein Bazooka/Par-3 and targets actomyosin cable assembly to the epidermal leading edge, thus establishing the migration direction of the developing epidermis.
Neural integrity is maintained by dystrophin in C. elegans
The dystrophin protein complex, an important regulator of muscle membrane integrity, also maintains neural organization through interactions with the L1CAM family member SAX-7.
