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Proteoglycan ensures that the Hedgehog protein and its receptor make a connection.

People & Ideas

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Special Focus

Stenmark studies how FYVE-finger proteins control cellular membrane dynamics.

Review

Report

Alterations in sphingosine kinase activity change the degradation rates of Rhodopsin and the transient receptor potential (TRP) channel by lysosomes and can result in retinal degeneration.

Article

Chromatin structure imposed by condensin II at centromeres enables xHJURP-mediated incorporation of CENP-A.

In the absence of Cbk1 phosphorylation Ssd1-associated mRNAs are redirected from sites of polarized cell growth to stress granules and P-bodies.

Alteration of the normal pattern and dynamics of Tem1 localization interferes with spindle checkpoint function and demonstrates that MEN signaling must initiate in the SPBs.

The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy.

Polycystin-2 goes through the Golgi apparatus when going to the plasma membrane, but bypasses it en route to the ciliary membrane.

The R406W mutation prevents tau from functioning as a linker between the membrane and the microtubule cytoskeleton.

The T cell receptor–activated tyrosine kinase Lck controls docking of the centrosome at the plasma membrane within the immunological synapse but not polarization of the centrosome around the nucleus.

Signaling from immunotyrosine-based inhibitory motifs (ITIMs) neutralizes activating signals by inducing a retraction of NK cells from the surface of stimulatory cells.

Binding between the Hedgehog ligand and its receptor Patched 1 is stabilized by Glypican-5.

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