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    On the cover
    Electron micrograph of wild-type Drosophila photoreceptors. Yonamine et al. demonstrate that overexpressing sphingosine kinase 2 causes photoreceptor degeneration and boosts the lysosomal degradation of light-sensing proteins such as Rhodopsin by increasing the levels of dihydrosphingosine 1 phosphate compared to sphingosine 1 phosphate. Image courtesy of Kunio Nagashima, Jairaj Acharya, and Usha Acharya.
    See page 557.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Proteoglycan ensures that the Hedgehog protein and its receptor make a connection.

People & Ideas

Stenmark studies how FYVE-finger proteins control cellular membrane dynamics.



Alterations in sphingosine kinase activity change the degradation rates of Rhodopsin and the transient receptor potential (TRP) channel by lysosomes and can result in retinal degeneration.


Chromatin structure imposed by condensin II at centromeres enables xHJURP-mediated incorporation of CENP-A.

In the absence of Cbk1 phosphorylation Ssd1-associated mRNAs are redirected from sites of polarized cell growth to stress granules and P-bodies.

Alteration of the normal pattern and dynamics of Tem1 localization interferes with spindle checkpoint function and demonstrates that MEN signaling must initiate in the SPBs.

The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy.

Polycystin-2 goes through the Golgi apparatus when going to the plasma membrane, but bypasses it en route to the ciliary membrane.

The R406W mutation prevents tau from functioning as a linker between the membrane and the microtubule cytoskeleton.

The T cell receptor–activated tyrosine kinase Lck controls docking of the centrosome at the plasma membrane within the immunological synapse but not polarization of the centrosome around the nucleus.

Signaling from immunotyrosine-based inhibitory motifs (ITIMs) neutralizes activating signals by inducing a retraction of NK cells from the surface of stimulatory cells.

Binding between the Hedgehog ligand and its receptor Patched 1 is stabilized by Glypican-5.

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