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Journal Articles

Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

In Special Collection:

JGP Highlights Collection 2025

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson

J Gen Physiol (2024) 157 (1): e202413609.

https://doi.org/10.1085/jgp.202413609

Published: 16 December 2024

View article titled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Journal Articles

Epilepsy-associated SCN2A (Na_V1.2) variants exhibit diverse and complex functional properties

In Special Collection:

Biophysics 2024 , Molecular Insights into Membrane Protein Function , Neuroscience Collection 2023

Christopher H. Thompson, Franck Potet, Tatiana V. Abramova, Jean-Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye, John J. Millichap, Alfred L. George, Jr

J Gen Physiol (2023) 155 (10): e202313375.

https://doi.org/10.1085/jgp.202313375

Published: 14 August 2023

View article titled, Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties

Includes: Supplementary data

Journal Articles

How does flecainide impact RyR2 channel function?

Samantha C. Salvage, Christopher L.-H. Huang, James A. Fraser, Angela F. Dulhunty

J Gen Physiol (2022) 154 (9): e202213089.

https://doi.org/10.1085/jgp.202213089

Published: 17 June 2022

View article titled, How does flecainide impact RyR2 channel function?

Journal Articles

Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

Angela F. Dulhunty, James A. Fraser, Christopher L.-H. Huang, Samantha C. Salvage

J Gen Physiol (2021) 154 (9): e2021ecc42.

https://doi.org/10.1085/jgp.2021ecc42

Published: 12 November 2021

View article titled, Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

Journal Articles

Intercalated disk nanoscale structure regulates cardiac conduction

In Special Collection:

Ion Channels Update 2022

Nicolae Moise, Heather L. Struckman, Celine Dagher, Rengasayee Veeraraghavan, Seth H. Weinberg

J Gen Physiol (2021) 153 (8): e202112897.

https://doi.org/10.1085/jgp.202112897

Published: 15 July 2021

View article titled, Intercalated disk nanoscale structure regulates cardiac conduction

Includes: Supplementary data

Journal Articles

E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms

Colin H. Peters, Abeline R. Watkins, Olivia L. Poirier, Peter C. Ruben

J Gen Physiol (2020) 152 (9): e202012595.

https://doi.org/10.1085/jgp.202012595

Published: 22 June 2020

View article titled, E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms

Includes: Supplementary data

Journal Articles

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Christopher H. Thompson, Roy Ben-Shalom, Kevin J. Bender, Alfred L. George, Jr.

J Gen Physiol (2020) 152 (3): e201912442.

https://doi.org/10.1085/jgp.201912442

Published: 29 January 2020

View article titled, Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Journal Articles

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

Huaying Zhao, Anthony J. Berger, Patrick H. Brown, Janesh Kumar, Andrea Balbo, Carrie A. May, Ernesto Casillas, Jr., Thomas M. Laue, George H. Patterson, Mark L. Mayer, Peter Schuck

J Gen Physiol (2013) 141 (6): 747–749.

https://doi.org/10.1085/jgp.20121077004292013c

Published: 27 May 2013

View article titled, Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

Journal Articles

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

Huaying Zhao, Anthony J. Berger, Patrick H. Brown, Janesh Kumar, Andrea Balbo, Carrie A. May, Ernesto Casillas, Jr., Thomas M. Laue, George H. Patterson, Mark L. Mayer, Peter Schuck

J Gen Physiol (2012) 139 (5): 371–388.

https://doi.org/10.1085/jgp.201210770

Published: 16 April 2012

View article titled, Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

Includes: Supplementary data

Journal Articles

An analysis of the relationships between subthreshold electrical properties and excitability in skeletal muscle

Thomas H. Pedersen, Christopher L.-H. Huang, James A. Fraser

J Gen Physiol (2011) 138 (1): 73–93.

https://doi.org/10.1085/jgp.201010510

Published: 13 June 2011

View article titled, An analysis of the relationships between subthreshold electrical properties and excitability in skeletal muscle

Journal Articles

Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle

James A. Fraser, Christopher L.-H. Huang, Thomas H. Pedersen

J Gen Physiol (2011) 138 (1): 95–116.

https://doi.org/10.1085/jgp.201110617

Published: 13 June 2011

View article titled, Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle

Journal Articles

Single-channel Properties of Human Na_V1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

Carlos G. Vanoye, Christoph Lossin, Thomas H. Rhodes, Alfred L. George, Jr.

J Gen Physiol (2005) 127 (1): 1–14.

https://doi.org/10.1085/jgp.200509373

Published: 27 December 2005

View article titled, Single-channel Properties of Human NaV1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

Journal Articles

Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels

Xiang D. Tang, Heather Daggett, Markus Hanner, Maria L. Garcia, Owen B. McManus, Nathan Brot, Herbert Weissbach, Stefan H. Heinemann, Toshinori Hoshi

J Gen Physiol (2001) 117 (3): 253–274.

https://doi.org/10.1085/jgp.117.3.253

Published: 26 February 2001

View article titled, Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels

Journal Articles

Correction

Wang, H.-L., A. Auerbach, N. Bren, K. Ohno, A.G. Engel, S.M. Sine

J Gen Physiol (1997) 110 (2): 215.

https://doi.org/10.1085/jgp.110.2.215

Published: 01 August 1997

View article titled, Correction

Journal Articles

Persistent activation of transducin by bleached rhodopsin in salamander rods.

H R Matthews, M C Cornwall, G L Fain

J Gen Physiol (1996) 108 (6): 557–563.

https://doi.org/10.1085/jgp.108.6.557

Published: 01 December 1996

View article titled, Persistent activation of transducin by bleached rhodopsin in salamander rods.

Journal Articles

Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.

D L Campbell, J S Stamler, H C Strauss

J Gen Physiol (1996) 108 (4): 277–293.

https://doi.org/10.1085/jgp.108.4.277

Published: 01 October 1996

View article titled, Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.

Journal Articles

Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker.

L J Hayward, R H Brown, Jr, S C Cannon

J Gen Physiol (1996) 107 (5): 559–576.

https://doi.org/10.1085/jgp.107.5.559

Published: 01 May 1996

View article titled, Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker.

Journal Articles

Bleached pigment activates transduction in salamander cones.

M C Cornwall, H R Matthews, R K Crouch, G L Fain

J Gen Physiol (1995) 106 (3): 543–557.

https://doi.org/10.1085/jgp.106.3.543

Published: 01 September 1995

View article titled, Bleached pigment activates transduction in salamander cones.

Journal Articles

Contrast gain control in the lower vertebrate retinas.

H M Sakai, J L Wang, K Naka

J Gen Physiol (1995) 105 (6): 815–835.

https://doi.org/10.1085/jgp.105.6.815

Published: 01 June 1995

View article titled, Contrast gain control in the lower vertebrate retinas.

Journal Articles

The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine.

D L Campbell, Y Qu, R L Rasmusson, H C Strauss

J Gen Physiol (1993) 101 (4): 603–626.

https://doi.org/10.1085/jgp.101.4.603

Published: 01 April 1993

View article titled, The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine.

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Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

Epilepsy-associated SCN2A (Na_V1.2) variants exhibit diverse and complex functional properties

How does flecainide impact RyR2 channel function?

Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

Intercalated disk nanoscale structure regulates cardiac conduction

E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

Analysis of high-affinity assembly for AMPA receptor amino-terminal domains

An analysis of the relationships between subthreshold electrical properties and excitability in skeletal muscle

Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle

Single-channel Properties of Human Na_V1.1 and Mechanism of Channel Dysfunction in SCN1A-associated Epilepsy

Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels

Correction

Persistent activation of transducin by bleached rhodopsin in salamander rods.

Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.

Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker.

Bleached pigment activates transduction in salamander cones.

Contrast gain control in the lower vertebrate retinas.

The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine.

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