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Stimulation of muscarinic Gq-coupled receptors initially depletes phosphoinositide phosphatidylinositol 4,5-bisphosphate from the plasma membrane. Myeong et al. show that phosphoinositides subsequently regenerate during sustained receptor stimulation as a consequence of profound PI 4-kinase pathway acceleration and not desensitization of receptors.

Cardiac small-conductance Ca2+-activated K+ (SK) channels are gated solely by beat-to-beat changes in intracellular Ca2+. Ledford et al. show distinct mechanisms by which human calmodulin mutants linked to sudden cardiac death regulate SK channels.

Hays et al. studied glutamate release to understand how light-evoked responses are encoded at rod ribbon synapses. Individual vesicles fused stochastically in hyperpolarized rods, whereas release at depolarized potentials attained in darkness occurred in semiregular bursts of 10–20 vesicles.

Commentary

New findings by Myeong et al. provide further details on how cells maintain their plasma membrane PI(4,5)P2 levels when stimulated via M1 muscarinic receptors

Research News

JGP study shows that small voltage changes disrupt semi-regular bursts of vesicle release from rod photoreceptors, potentially facilitating low-light vision.

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