Issues
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Cover Image
Cover Image
ON THE COVER
Ultrasound neuromodulation in acute brain slices. Top left: Ultrasound is applied to hippo-campal pyramidal neurons under current clamp. Top right: Voltage traces showing inhibition of action potential firing by ultrasound. Bottom: Raster plots and spike-time histograms for control and ultrasound conditions. While this example shows inhibition of firing, ultrasound can either inhibit or potentiate firing depending on firing rate. Image © Prieto et al., 2020. See http://doi.org/10.1085/jgp.202012672. - PDF Icon PDF LinkTable of Contents
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Research News
A new window into large-pore channels
JGP study describes a novel quantitative assay combining fluorescence microscopy and electrophysiology, which reveals that transport of small molecules through CALHM1 and connexin channels is saturable
Commentary
Just how many holes…?
Neginskaya et al. discuss the very low number of calcium-induced permeability transition pores in the single mitochondrion.
Reviews
ATP synthase: Evolution, energetics, and membrane interactions
This review outlines a holistic framework for studying ATP synthase and emphasizes the importance of considering interactions with the lipid environment in shaping the function and evolutionary history of membrane proteins.
Articles
Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling
The present work shows that SR Ca2+ load and RYR2 Ca2+ sensitivity are major determinants of Ca2+ release restitution (CRR) after each heartbeat. Mathematical modeling led us to speculate that the velocity of SR Ca2+ refilling might regulate CRR independently of SR Ca2+ content.
Spike frequency–dependent inhibition and excitation of neural activity by high-frequency ultrasound
Prieto et al. describe how ultrasound can either inhibit or potentiate action potential firing in hippocampal pyramidal neurons and demonstrate that these effects can be explained by increased potassium conductance.
Methods and Approaches
A novel voltage-clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channels
Gaete et al. have designed a methodology that allows quantitative analysis of the permeation of ions and molecules through connexin and CALHM1 large-pore channels. Both channels display saturable transport of molecules that could be described by Michaelis-Menten kinetics with apparent Km and Vmax.
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