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Volume 135, Issue 5

1 May 2010

Journal of General Physiology Cover Image for Volume 135, Issue 5

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Cover Image

Cover Image

Cover picture: State-dependent ligand exchange in NBD1 during CFTR gating. (Top left) PPi-induced lock-open state represents an NBD dimer with ATP in NBD1 and PPi in NBD2. (Top right) A hypothetic scheme depicting a possible ligand exchange in the lock-open state. (Bottom) The lock-open time was not significantly prolonged when the solution was switched from ATP+PPi (red) to PATP+PPi (blue) for 2 min, suggesting negligible ATP/PATP exchange in NBD1 in the lock-open state (see article by Tsai et al., 399–414).
Table of Contents
Editorial Board

ISSN 0022-1295

EISSN 1540-7748

In this Issue

Editorial
Commentary
Article

Editorial

New style, same substance

Mike Rossner

View Articletitled, New style, same substance

Commentary

Degenerate ABC composite site is stably glued together by trapped ATP

László Csanády

View Articletitled, Degenerate ABC composite site is stably glued together by trapped ATP

Article

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Ming-Feng Tsai,Min Li,Tzyh-Chang Hwang

View Articletitled, Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Transfer of ion binding site from ether-à-go-go to Shaker: Mg²⁺ binds to resting state to modulate channel opening

Meng-chin A. Lin,Jeff Abramson,Diane M. Papazian

View Articletitled, Transfer of ion binding site from ether-à-go-go to Shaker: Mg<sup>2+</sup> binds to resting state to modulate channel opening

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of I_Ks

Jodene Eldstrom,Hongjian Xu,Daniel Werry,Congbao Kang,Matthew E. Loewen,Amanda Degenhardt,Shubhayan Sanatani,Glen F. Tibbits,Charles Sanders,David Fedida

View Articletitled, Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of <em>I<sub>Ks</sub></em>

Location of modulatory β subunits in BK potassium channels

Guoxia Liu,Xiaowei Niu,Roland S. Wu,Neelesh Chudasama,Yongneng Yao,Xin Jin,Richard Weinberg,Sergey I. Zakharov,Howard Motoike,Steven O. Marx,Arthur Karlin

View Articletitled, Location of modulatory β subunits in BK potassium channels

Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca²⁺

Christopher Shelley,Xiaowei Niu,Yanyan Geng,Karl L. Magleby

View Articletitled, Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca<sup>2+</sup>

Glycine₃₁₁, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix

Yu Zhou,Qiong-Yao Tang,Xiao-Ming Xia,Christopher J. Lingle

View Articletitled, Glycine<sub>311</sub>, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix

Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1

Harley T. Kurata,Emily A. Zhu,Colin G. Nichols

View Articletitled, Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1

Allosteric mechanism of Ca²⁺ activation and H⁺-inhibited gating of the MthK K⁺ channel

Victor P.T. Pau,Karin Abarca-Heidemann,Brad S. Rothberg

View Articletitled, Allosteric mechanism of Ca<sup>2+</sup> activation and H<sup>+</sup>-inhibited gating of the MthK K<sup>+</sup> channel

Cyclic AMP potentiates Ca²⁺-dependent exocytosis in pancreatic duct epithelial cells

Seung-Ryoung Jung,Bertil Hille,Toan D. Nguyen,Duk-Su Koh

View Articletitled, Cyclic AMP potentiates Ca<sup>2+</sup>-dependent exocytosis in pancreatic duct epithelial cells

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The physical basis of osmosis

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Mechanotransduction by Membrane Proteins

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

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