Issues

Cover picture: State-dependent ligand exchange in NBD1 during CFTR gating. (Top left) PPi-induced lock-open state represents an NBD dimer with ATP in NBD1 and PPi in NBD2. (Top right) A hypothetic scheme depicting a possible ligand exchange in the lock-open state. (Bottom) The lock-open time was not significantly prolonged when the solution was switched from ATP+PPi (red) to PATP+PPi (blue) for 2 min, suggesting negligible ATP/PATP exchange in NBD1 in the lock-open state (see article by Tsai et al., 399–414).