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Christopher J. Lingle
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Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells

In Special Collection:
Neuroscience Collection 2021
Pedro L. Martinez-Espinosa, Chengtao Yang, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (4): e202012785.
https://doi.org/10.1085/jgp.202012785
Published: 02 March 2021
View article titled, Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells
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Journal Articles

Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways

In Special Collection:
Neuroscience Collection 2021
Pedro L. Martinez-Espinosa, Alan Neely, Jiuping Ding, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2021) 153 (4): e202012784.
https://doi.org/10.1085/jgp.202012784
Published: 01 March 2021
View article titled, Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways
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Journal Articles

Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel

In Special Collection:
Ion Channel Structure & Function 2018 , JGP Reviews: Ion Channel Structure and Function
Yu Zhou, Huanghe Yang, Jianmin Cui, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2017) 149 (11): 985–1007.
https://doi.org/10.1085/jgp.201711845
Published: 12 October 2017
View article titled, Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel
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Includes: Supplementary data
Journal Articles

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism

Yu Zhou, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2014) 144 (5): 415–440.
https://doi.org/10.1085/jgp.201411259
Published: 27 October 2014
View article titled, Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
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Journal Articles

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity

Pedro L. Martinez-Espinosa, Chengtao Yang, Vivian Gonzalez-Perez, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2014) 144 (4): 275–295.
https://doi.org/10.1085/jgp.201411253
Published: 29 September 2014
View article titled, Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
Open the PDF for Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity in another window
Includes: Supplementary data
Journal Articles

Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa

Xu-Hui Zeng, Betsy Navarro, Xiao-Ming Xia, David E. Clapham, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2013) 142 (3): 305–313.
https://doi.org/10.1085/jgp.201311011
Published: 26 August 2013
View article titled, Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
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Journal Articles

Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix

Yu Zhou, Qiong-Yao Tang, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2010) 135 (5): 481–494.
https://doi.org/10.1085/jgp.201010403
Published: 26 April 2010
View article titled, Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
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Journal Articles

Closed-channel block of BK potassium channels by bbTBA requires partial activation

Qiong-Yao Tang, Xu-Hui Zeng, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2009) 134 (5): 409–436.
https://doi.org/10.1085/jgp.200910251
Published: 26 October 2009
View article titled, Closed-channel block of BK potassium channels by bbTBA requires partial activation
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Includes: Supplementary data
Journal Articles

N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels

Zhe Zhang, Xu-Hui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2009) 133 (3): 263–282.
https://doi.org/10.1085/jgp.200810079
Published: 23 February 2009
View article titled, N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels
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Includes: Supplementary data
Journal Articles

Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits

Xuhui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2008) 132 (1): 115–129.
https://doi.org/10.1085/jgp.200809969
Published: 30 June 2008
View article titled, Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits
Open the PDF for Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits in another window
Includes: Supplementary data
Journal Articles

Mg2+-dependent Regulation of BK Channels: Importance of Electrostatics

Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2007) 131 (1): 5–11.
https://doi.org/10.1085/jgp.200709937
Published: 31 December 2007
View article titled, Mg2+-dependent Regulation of BK Channels: Importance of Electrostatics
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Journal Articles

Gating Rings Formed by RCK Domains: Keys to Gate Opening

Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2007) 129 (2): 101–107.
https://doi.org/10.1085/jgp.200709739
Published: 29 January 2007
View article titled, Gating Rings Formed by RCK Domains: Keys to Gate Opening
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Journal Articles

pH-regulated Slo3 K+ Channels: Properties of Unitary Currents

Xue Zhang, Xuhui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (3): 301–315.
https://doi.org/10.1085/jgp.200609551
Published: 28 August 2006
View article titled, pH-regulated Slo3 K+ Channels: Properties of Unitary Currents
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Journal Articles

Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents

Xue Zhang, Xuhui Zeng, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 128 (3): 317–336.
https://doi.org/10.1085/jgp.200609552
Published: 28 August 2006
View article titled, Slo3 K+ Channels: Voltage and pH Dependence of Macroscopic Currents
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Journal Articles

Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits

G. Richard Benzinger, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2006) 127 (2): 119–131.
https://doi.org/10.1085/jgp.200509425
Published: 17 January 2006
View article titled, Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits
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Journal Articles

Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites

Xu-Hui Zeng, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2005) 125 (3): 273–286.
https://doi.org/10.1085/jgp.200409239
Published: 28 February 2005
View article titled, Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites
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Journal Articles

Inactivation of BK Channels by the NH2 Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues

Xiao-Ming Xia, J.P. Ding, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2003) 121 (2): 125–148.
https://doi.org/10.1085/jgp.20028667
Published: 03 February 2003
View article titled, Inactivation of BK Channels by the NH2 Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues
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Journal Articles

Setting the Stage for Molecular Dissection of the Regulatory Components of BK Channels

Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2002) 120 (3): 261–265.
https://doi.org/10.1085/jgp.20028689
Published: 26 August 2002
View article titled, Setting the Stage for Molecular Dissection of the Regulatory Components of BK Channels
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Journal Articles

Gating Properties Conferred on Bk Channels by the β3b Auxiliary Subunit in the Absence of Its Nh2- and Cooh Termini

Xu-Hui Zeng, J.-P. Ding, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2001) 117 (6): 607–628.
https://doi.org/10.1085/jgp.117.6.607
Published: 29 May 2001
View article titled, Gating Properties Conferred on Bk Channels by the β3b Auxiliary Subunit in the Absence of Its Nh2- and Cooh Termini
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