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Journal Articles

Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

In Special Collection:

Ion channel modulation

Han-I Yeh, Liming Qiu, Yoshiro Sohma, Katja Conrath, Xiaoqin Zou, Tzyh-Chang Hwang

J Gen Physiol (2019) 151 (7): 912–928.

https://doi.org/10.1085/jgp.201912360

Published: 04 June 2019

View article titled, Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

Includes: Multimedia, Supplementary data

Journal Articles

Structural mechanisms of CFTR function and dysfunction

In Special Collection:

Ion Channel Structure & Function 2018 , JGP Reviews: Ion Channel Structure and Function , Molecular Biophysics of Membranes 2018

Tzyh-Chang Hwang, Jiunn-Tyng Yeh, Jingyao Zhang, Ying-Chun Yu, Han-I Yeh, Samantha Destefano

J Gen Physiol (2018) 150 (4): 539–570.

https://doi.org/10.1085/jgp.201711946

Published: 26 March 2018

View article titled, Structural mechanisms of CFTR function and dysfunction

Includes: Supplementary data

Journal Articles

A common mechanism for CFTR potentiators

Han-I Yeh, Yoshiro Sohma, Katja Conrath, Tzyh-Chang Hwang

J Gen Physiol (2017) 149 (12): 1105–1118.

https://doi.org/10.1085/jgp.201711886

Published: 27 October 2017

View article titled, A common mechanism for CFTR potentiators

Includes: Supplementary data

Journal Articles

Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

Jingyao Zhang, Tzyh-Chang Hwang

J Gen Physiol (2017) 149 (3): 355–372.

https://doi.org/10.1085/jgp.201611664

Published: 27 February 2017

View article titled, Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

Includes: Supplementary data

Journal Articles

Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

Xiaolong Gao, Tzyh-Chang Hwang

J Gen Physiol (2016) 147 (5): 407–422.

https://doi.org/10.1085/jgp.201511557

Published: 25 April 2016

View article titled, Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

Includes: Supplementary data

Journal Articles

Modulation of CFTR gating by permeant ions

Han-I Yeh, Jiunn-Tyng Yeh, Tzyh-Chang Hwang

J Gen Physiol (2014) 145 (1): 47–60.

https://doi.org/10.1085/jgp.201411272

Published: 15 December 2014

View article titled, Modulation of CFTR gating by permeant ions

Includes: Multimedia, Supplementary data

Journal Articles

A single amino acid substitution in CFTR converts ATP to an inhibitory ligand

Wen-Ying Lin, Kang-Yang Jih, Tzyh-Chang Hwang

J Gen Physiol (2014) 144 (4): 311–320.

https://doi.org/10.1085/jgp.201411247

Published: 15 September 2014

View article titled, A single amino acid substitution in CFTR converts ATP to an inhibitory ligand

Journal Articles

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

Kang-Yang Jih, Yoshiro Sohma, Tzyh-Chang Hwang

J Gen Physiol (2012) 140 (4): 347–359.

https://doi.org/10.1085/jgp.201210834

Published: 10 September 2012

View article titled, Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

Includes: Supplementary data

Journal Articles

Identification of a novel post-hydrolytic state in CFTR gating

Kang-Yang Jih, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2012) 139 (5): 359–370.

https://doi.org/10.1085/jgp.201210789

Published: 16 April 2012

View article titled, Identification of a novel post-hydrolytic state in CFTR gating

Includes: Supplementary data

Journal Articles

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

Yonghong Bai, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2011) 138 (5): 495–507.

https://doi.org/10.1085/jgp.201110705

Published: 31 October 2011

View article titled, Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

Includes: Supplementary data

Journal Articles

On the mechanism of CFTR inhibition by a thiazolidinone derivative

Zoia Kopeikin, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2010) 136 (6): 659–671.

https://doi.org/10.1085/jgp.201010518

Published: 15 November 2010

View article titled, On the mechanism of CFTR inhibition by a thiazolidinone derivative

Includes: Supplementary data

Journal Articles

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

Yonghong Bai, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2010) 136 (3): 293–309.

https://doi.org/10.1085/jgp.201010480

Published: 30 August 2010

View article titled, Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

Journal Articles

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Ming-Feng Tsai, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2010) 135 (5): 399–414.

https://doi.org/10.1085/jgp.201010399

Published: 26 April 2010

View article titled, Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Includes: Supplementary data

Journal Articles

State-dependent modulation of CFTR gating by pyrophosphate

Ming-Feng Tsai, Hiroyasu Shimizu, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2009) 133 (4): 405–419.

https://doi.org/10.1085/jgp.200810186

Published: 30 March 2009

View article titled, State-dependent modulation of CFTR gating by pyrophosphate

Includes: Supplementary data

Journal Articles

Mutations at the Signature Sequence of CFTR Create a Cd²⁺-gated Chloride Channel

Xiaohui Wang, Silvia G. Bompadre, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2008) 133 (1): 69–77.

https://doi.org/10.1085/jgp.200810049

Published: 29 December 2008

View article titled, Mutations at the Signature Sequence of CFTR Create a Cd<sup>2+</sup>-gated Chloride Channel

Includes: Supplementary data

Journal Articles

G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating Defects

Silvia G. Bompadre, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2007) 129 (4): 285–298.

https://doi.org/10.1085/jgp.200609667

Published: 12 March 2007

View article titled, G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating Defects

Journal Articles

The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

Zhen Zhou, Xiaohui Wang, Hao-Yang Liu, Xiaoqin Zou, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2006) 128 (4): 413–422.

https://doi.org/10.1085/jgp.200609622

Published: 11 September 2006

View article titled, The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

Includes: Supplementary data

Journal Articles

CFTR Gating I : Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)

Silvia G. Bompadre, Tomohiko Ai, Jeong Han Cho, Xiaohui Wang, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2005) 125 (4): 361–375.

https://doi.org/10.1085/jgp.200409227

Published: 14 March 2005

View article titled, CFTR Gating I : <subtitle>Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR) </subtitle>

Includes: Supplementary data

Journal Articles

CFTR Gating II : Effects of Nucleotide Binding on the Stability of Open States

Silvia G. Bompadre, Jeong Han Cho, Xiaohui Wang, Xiaoqin Zou, Yoshiro Sohma, Min Li, Tzyh-Chang Hwang

J Gen Physiol (2005) 125 (4): 377–394.

https://doi.org/10.1085/jgp.200409228

Published: 14 March 2005

View article titled, CFTR Gating II : <subtitle>Effects of Nucleotide Binding on the Stability of Open States </subtitle>

Includes: Supplementary data

Journal Articles

Probing an Open CFTR Pore with Organic Anion Blockers

Zhen Zhou, Shenghui Hu, Tzyh-Chang Hwang

J Gen Physiol (2002) 120 (5): 647–662.

https://doi.org/10.1085/jgp.20028685

Published: 14 October 2002

View article titled, Probing an Open CFTR Pore with Organic Anion Blockers

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Filters

Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

Structural mechanisms of CFTR function and dysfunction

A common mechanism for CFTR potentiators

Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

Modulation of CFTR gating by permeant ions

A single amino acid substitution in CFTR converts ATP to an inhibitory ligand

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

Identification of a novel post-hydrolytic state in CFTR gating

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

On the mechanism of CFTR inhibition by a thiazolidinone derivative

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

State-dependent modulation of CFTR gating by pyrophosphate

Mutations at the Signature Sequence of CFTR Create a Cd²⁺-gated Chloride Channel

G551D and G1349D, Two CF-associated Mutations in the Signature Sequences of CFTR, Exhibit Distinct Gating Defects

The Two ATP Binding Sites of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Play Distinct Roles in Gating Kinetics and Energetics

CFTR Gating I : Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)

CFTR Gating II : Effects of Nucleotide Binding on the Stability of Open States

Probing an Open CFTR Pore with Organic Anion Blockers

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