Page 1 | Search Results | Journal of Experimental Medicine

1-20 of 51

Sort by

Sort Order Select

Journal Articles

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

J Exp Med (2023) 220 (9): e20230054.

https://doi.org/10.1084/jem.20230054

Published: 18 July 2023

View article titled, TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Journal Articles

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Michelle S.J. Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B. Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A. Katharina Simon, Jelena S. Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J. Ishii, Cevayir Coban

J Exp Med (2021) 219 (2): e20211336.

https://doi.org/10.1084/jem.20211336

Published: 15 December 2021

View article titled, B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Includes: Supplementary data

Journal Articles

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response

Hiroki Tanaka, Yasunobu Arima, Daisuke Kamimura, Yuki Tanaka, Noriyuki Takahashi, Takuya Uehata, Kazuhiko Maeda, Takashi Satoh, Masaaki Murakami, Shizuo Akira

J Exp Med (2019) 216 (6): 1431–1449.

https://doi.org/10.1084/jem.20181078

Published: 09 May 2019

View article titled, Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response

Includes: Supplementary data

Journal Articles

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

J Exp Med (2019) 216 (2): 267–278.

https://doi.org/10.1084/jem.20180729

Published: 11 January 2019

View article titled, Heterozygous <em>Tbk1</em> loss has opposing effects in early and late stages of ALS in mice

Includes: Supplementary data

Journal Articles

Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

Pengyan Xia, Shuo Wang, Ying Du, Guanling Huang, Takashi Satoh, Shizuo Akira, Zusen Fan

J Exp Med (2015) 212 (13): 2305–2321.

https://doi.org/10.1084/jem.20150618

Published: 16 November 2015

View article titled, Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

Includes: Supplementary data

Journal Articles

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Michelle Goritzka, Spyridon Makris, Fahima Kausar, Lydia R. Durant, Catherine Pereira, Yutaro Kumagai, Fiona J. Culley, Matthias Mack, Shizuo Akira, Cecilia Johansson

J Exp Med (2015) 212 (5): 699–714.

https://doi.org/10.1084/jem.20140825

Published: 20 April 2015

View article titled, Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Includes: Supplementary data

Journal Articles

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

Kenta Maruyama, Satoshi Uematsu, Takeshi Kondo, Osamu Takeuchi, Mikaël M. Martino, Takumi Kawasaki, Shizuo Akira

J Exp Med (2013) 210 (10): 1947–1960.

https://doi.org/10.1084/jem.20130512

Published: 26 August 2013

View article titled, Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

Journal Articles

B cells enhance early innate immune responses during bacterial sepsis

Kindra M. Kelly-Scumpia, Philip O. Scumpia, Jason S. Weinstein, Matthew J. Delano, Alex G. Cuenca, Dina C. Nacionales, James L. Wynn, Pui Y. Lee, Yutaro Kumagai, Philip A. Efron, Shizuo Akira, Clive Wasserfall, Mark A. Atkinson, Lyle L. Moldawer

J Exp Med (2011) 208 (8): 1673–1682.

https://doi.org/10.1084/jem.20101715

Published: 11 July 2011

View article titled, B cells enhance early innate immune responses during bacterial sepsis

Includes: Supplementary data

Journal Articles

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki

J Exp Med (2009) 206 (13): 2879–2888.

https://doi.org/10.1084/jem.20091750

Published: 14 December 2009

View article titled, Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Includes: Supplementary data

Journal Articles

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

Melanie L. Conrad, Ruth Ferstl, René Teich, Stephanie Brand, Nicole Blümer, Ali Ö. Yildirim, Cecilia C. Patrascan, Anna Hanuszkiewicz, Shizuo Akira, Hermann Wagner, Otto Holst, Erika von Mutius, Petra I. Pfefferle, Carsten J. Kirschning, Holger Garn, Harald Renz

J Exp Med (2009) 206 (13): 2869–2877.

https://doi.org/10.1084/jem.20090845

Published: 07 December 2009

View article titled, Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe <em>Acinetobacter lwoffii</em> F78

Journal Articles

Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

J Exp Med (2009) 206 (11): 2351–2364.

https://doi.org/10.1084/jem.20091436

Published: 12 October 2009

View article titled, Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Includes: Supplementary data

Journal Articles

Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

Tomohiro Kubo, Yuki Uchida, Yuko Watanabe, Masahiro Abe, Akira Nakamura, Masao Ono, Shizuo Akira, Toshiyuki Takai

J Exp Med (2009) 206 (9): 1971–1982.

https://doi.org/10.1084/jem.20082392

Published: 17 August 2009

View article titled, Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

Includes: Supplementary data

Journal Articles

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, Russell E. Vance

J Exp Med (2009) 206 (9): 1899–1911.

https://doi.org/10.1084/jem.20082874

Published: 03 August 2009

View article titled, A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Includes: Supplementary data

Journal Articles

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

Pui Y. Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S. Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira, Westley H. Reeves

J Exp Med (2008) 205 (13): 2995–3006.

https://doi.org/10.1084/jem.20080462

Published: 01 December 2008

View article titled, TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

Includes: Supplementary data

Journal Articles

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, Reiko Hirai, Tomoji Kawai, Kazufumi Matsushita, Akane Hiiragi, Terence S. Dermody, Takashi Fujita, Shizuo Akira

J Exp Med (2008) 205 (7): 1601–1610.

https://doi.org/10.1084/jem.20080091

Published: 30 June 2008

View article titled, Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

Includes: Supplementary data

Journal Articles

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

Minghui Tang, Xudong Wei, Yinshi Guo, Peter Breslin, Shubin Zhang, Shanshan Zhang, Wei Wei, Zhenbiao Xia, Manuel Diaz, Shizuo Akira, Jiwang Zhang

J Exp Med (2008) 205 (7): 1611–1619.

https://doi.org/10.1084/jem.20080297

Published: 23 June 2008

View article titled, TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

Includes: Supplementary data

Journal Articles

Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira

J Exp Med (2007) 204 (9): 2233–2239.

https://doi.org/10.1084/jem.20070183

Published: 27 August 2007

View article titled, Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

Includes: Supplementary data

Journal Articles

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

Zachary J. Roberts, Nadege Goutagny, Pin-Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David van Echo, Katherine A. Fitzgerald, Howard A. Young, Lai-Ming Ching, Stefanie N. Vogel

J Exp Med (2007) 204 (7): 1559–1569.

https://doi.org/10.1084/jem.20061845

Published: 11 June 2007

View article titled, The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

Includes: Supplementary data

Journal Articles

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira

J Exp Med (2007) 204 (5): 1013–1024.

https://doi.org/10.1084/jem.20061523

Published: 07 May 2007

View article titled, Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

Includes: Supplementary data

Journal Articles

IL-21–induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses

Michishige Harada, Kumiko Magara-Koyanagi, Hiroshi Watarai, Yuko Nagata, Yasuyuki Ishii, Satoshi Kojo, Shigetoshi Horiguchi, Yoshitaka Okamoto, Toshinori Nakayama, Nobutaka Suzuki, Wen-Chen Yeh, Shizuo Akira, Hiroshi Kitamura, Osamu Ohara, Ken-ichiro Seino, Masaru Taniguchi

J Exp Med (2006) 203 (13): 2929–2937.

https://doi.org/10.1084/jem.20062206

Published: 18 December 2006

View article titled, IL-21–induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses

Includes: Supplementary data

NARROW

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

B cells enhance early innate immune responses during bacterial sepsis

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

IL-21–induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses

Email alerts

Email alerts

This Feature Is Available To Subscribers Only