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Journal Articles

The cribriform plate: A dynamic central nervous system–immune hub

In Special Collection:

Immunology Update Winter 2026

Collin J. Laaker, Sophia M. Vrba, Jenna M. Port, Martin Hsu, Cameron M. Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2025) 223 (2): e20251871.

https://doi.org/10.1084/jem.20251871

Published: 30 December 2025

View article titled, The cribriform plate: A dynamic central nervous system–immune hub

Journal Articles

T cell engagers emerge as a compelling therapeutic modality

In Special Collection:

Immunology Update Winter 2026

P.A. Baeuerle, K. Sauer, R. Grieshaber-Bouyer, J.S. Michaelson

J Exp Med (2025) 223 (2): e20251652.

https://doi.org/10.1084/jem.20251652

Published: 26 December 2025

View article titled, T cell engagers emerge as a compelling therapeutic modality

Journal Articles

Bringing natural killer cells to the clinic: Opportunities beyond cancer

Marjorie Cayatte, Valentin Picant, Marie Vétizou, Eric Vivier

J Exp Med (2025) 223 (1): e20250612.

https://doi.org/10.1084/jem.20250612

Published: 17 December 2025

View article titled, Bringing natural killer cells to the clinic: Opportunities beyond cancer

Journal Articles

Advances in the development of personalized neoantigen therapies

Spencer E. Mirabile-Brightman, Lisa H. Butterfield

J Exp Med (2025) 223 (2): e20241234.

https://doi.org/10.1084/jem.20241234

Published: 09 December 2025

View article titled, Advances in the development of personalized neoantigen therapies

Journal Articles

Monogenic disorders of the IRF transcription factors

Mattison P. Stojcic, Pariya Yousefi, Catherine M. Biggs, Stuart E. Turvey

J Exp Med (2025) 223 (1): e20250939.

https://doi.org/10.1084/jem.20250939

Published: 21 November 2025

View article titled, Monogenic disorders of the IRF transcription factors

Journal Articles

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Esmeralda Villavicencio Gonzalez, Huda Y. Zoghbi

J Exp Med (2025) 223 (1): e20241336.

https://doi.org/10.1084/jem.20241336

Published: 23 October 2025

View article titled, Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Journal Articles

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

In Special Collection:

Neuroscience Collection 2025

Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze

J Exp Med (2025) 222 (10): e20250965.

https://doi.org/10.1084/jem.20250965

Published: 26 August 2025

View article titled, ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Journal Articles

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

In Special Collection:

Cytokines Collection 2025

Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M. Adrover

J Exp Med (2025) 222 (9): e20242402.

https://doi.org/10.1084/jem.20242402

Published: 11 August 2025

View article titled, Heart of the matter: Neutrophils, cancer, and cardiovascular disease

Journal Articles

CD4⁺ T cell dysfunction in cancer

Hrishi Venkatesh, Lawrence Fong

J Exp Med (2025) 222 (9): e20241417.

https://doi.org/10.1084/jem.20241417

Published: 07 August 2025

View article titled, CD4+ T cell dysfunction in cancer

Journal Articles

Lipid metabolism and neuroinflammation: What is the link?

In Special Collection:

Macrophages and Dendritic Cells in Health and Disease , Neuroscience Collection 2025

Vini Tiwari, Mikael Simons

J Exp Med (2025) 222 (9): e20241232.

https://doi.org/10.1084/jem.20241232

Published: 05 August 2025

View article titled, Lipid metabolism and neuroinflammation: What is the link?

Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders

J Exp Med (2025) 222 (9): e20241433.

https://doi.org/10.1084/jem.20241433

Published: 31 July 2025

View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells

Journal Articles

YTHDFs as radiotherapy checkpoints in tumor immunity

In Special Collection:

JEM Cancer Immunotherapy 2025

Chuangyu Wen, Emile Z. Naccasha, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum

J Exp Med (2025) 222 (8): e20250272.

https://doi.org/10.1084/jem.20250272

Published: 05 June 2025

View article titled, YTHDFs as radiotherapy checkpoints in tumor immunity

Journal Articles

Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases

Natalia Reglero-Real, Loïc Rolas, Sussan Nourshargh

J Exp Med (2025) 222 (7): e20242154.

https://doi.org/10.1084/jem.20242154

Published: 02 June 2025

View article titled, Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases

Journal Articles

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Hanover C. Matz, Ali H. Ellebedy

J Exp Med (2025) 222 (7): e20241283.

https://doi.org/10.1084/jem.20241283

Published: 24 April 2025

View article titled, Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:

JEM Clinical Immunology Collection 2025

Andrew A. Almonte, Simon Thomas, Laurence Zitvogel

J Exp Med (2025) 222 (7): e20250378.

https://doi.org/10.1084/jem.20250378

Published: 22 April 2025

View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies

Journal Articles

Human immunity to fungal infections

In Special Collection:

JEM Clinical Immunology Collection 2025

Donald C. Vinh

J Exp Med (2025) 222 (6): e20241215.

https://doi.org/10.1084/jem.20241215

Published: 15 April 2025

View article titled, Human immunity to fungal infections

Journal Articles

Identifying genetic errors of immunity due to mosaicism

In Special Collection:

JEM Clinical Immunology Collection 2025 , Genes and Immunity

Elizabeth G. Schmitz, Malachi Griffith, Obi L. Griffith, Megan A. Cooper

J Exp Med (2025) 222 (5): e20241045.

https://doi.org/10.1084/jem.20241045

Published: 15 April 2025

View article titled, Identifying genetic errors of immunity due to mosaicism

Journal Articles

Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency

András N. Spaan, Bertrand Boisson, Seth L. Masters

J Exp Med (2025) 222 (5): e20241047.

https://doi.org/10.1084/jem.20241047

Published: 15 April 2025

View article titled, Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency

Journal Articles

Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment

In Special Collection:

Immunometabolism 2025

Ana Belén Plata-Gómez, Ping-Chih Ho

J Exp Med (2025) 222 (6): e20241102.

https://doi.org/10.1084/jem.20241102

Published: 11 April 2025

View article titled, Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment

Journal Articles

Lymphatic transport in anti-tumor immunity and metastasis

In Special Collection:

JEM Immunology Collection 2025 , JEM Cancer Collection 2025

Mengzhu Sun, Julien Angelillo, Stéphanie Hugues

J Exp Med (2025) 222 (3): e20231954.

https://doi.org/10.1084/jem.20231954

Published: 19 February 2025

View article titled, Lymphatic transport in anti-tumor immunity and metastasis

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The cribriform plate: A dynamic central nervous system–immune hub

T cell engagers emerge as a compelling therapeutic modality

Bringing natural killer cells to the clinic: Opportunities beyond cancer

Advances in the development of personalized neoantigen therapies

Monogenic disorders of the IRF transcription factors

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

CD4⁺ T cell dysfunction in cancer

Lipid metabolism and neuroinflammation: What is the link?

Epigenetic priming as a driver of memory recall and dysfunction in T cells

YTHDFs as radiotherapy checkpoints in tumor immunity

Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Microbiota-centered interventions to boost immune checkpoint blockade therapies

Human immunity to fungal infections

Identifying genetic errors of immunity due to mosaicism

Primary disorders of polyubiquitination: Dual roles in autoinflammation and immunodeficiency

Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment

Lymphatic transport in anti-tumor immunity and metastasis

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