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Journal Articles

LCK’ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated

Ahmet Eken, Sara A. Johnson, Serife Erdem, Elena W.Y. Hsieh
Journal: Journal of Experimental Medicine
Series: Genes and Immunity Focus
J Exp Med (2026) 223 (6): e20241046.
https://doi.org/10.1084/jem.20241046
Published: 05 May 2026
View article titled, LCK’ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated
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Includes: Supplementary data
Journal Articles

Inhibitory receptor agonists: Emerging strategies in immune modulation

In Special Collection:
Inflammation Resolution 2026
Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo, Dario A.A. Vignali
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20241217.
https://doi.org/10.1084/jem.20241217
Published: 31 March 2026
View article titled, Inhibitory receptor agonists: Emerging strategies in immune modulation
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Journal Articles

Rethinking disomy: Autosomal expression bias

Dusan Bogunovic
Journal: Journal of Experimental Medicine
Series: Genes and Immunity Focus
J Exp Med (2026) 223 (4): e20241044.
https://doi.org/10.1084/jem.20241044
Published: 23 March 2026
View article titled, Rethinking disomy: Autosomal expression bias
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Journal Articles

Myeloid diversity in tumors: Shaped by genes, location, and time

Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, María Casanova-Acebes
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20252267.
https://doi.org/10.1084/jem.20252267
Published: 12 March 2026
View article titled, Myeloid diversity in tumors: Shaped by genes, location, and time
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Journal Articles

The cribriform plate: A dynamic central nervous system–immune hub

In Special Collection:
Immunology Update Winter 2026 , Lymphatic Vessels in Health and Disease 2026
Collin J. Laaker, Sophia M. Vrba, Jenna M. Port, Martin Hsu, Cameron M. Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20251871.
https://doi.org/10.1084/jem.20251871
Published: 30 December 2025
View article titled, The cribriform plate: A dynamic central nervous system–immune hub
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Journal Articles

T cell engagers emerge as a compelling therapeutic modality

In Special Collection:
Immunology Update Winter 2026
P.A. Baeuerle, K. Sauer, R. Grieshaber-Bouyer, J.S. Michaelson
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 223 (2): e20251652.
https://doi.org/10.1084/jem.20251652
Published: 26 December 2025
View article titled, T cell engagers emerge as a compelling therapeutic modality
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Journal Articles

Bringing natural killer cells to the clinic: Opportunities beyond cancer

In Special Collection:
JEM Immunology Collection 2026
Marjorie Cayatte, Valentin Picant, Marie Vétizou, Eric Vivier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250612.
https://doi.org/10.1084/jem.20250612
Published: 17 December 2025
View article titled, Bringing natural killer cells to the clinic: Opportunities beyond cancer
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Journal Articles

Advances in the development of personalized neoantigen therapies

Spencer E. Mirabile-Brightman, Lisa H. Butterfield
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 223 (2): e20241234.
https://doi.org/10.1084/jem.20241234
Published: 09 December 2025
View article titled, Advances in the development of personalized neoantigen therapies
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Journal Articles

Monogenic disorders of the IRF transcription factors

In Special Collection:
Innate Immune Signaling in Infection and Disease
Mattison P. Stojcic, Pariya Yousefi, Catherine M. Biggs, Stuart E. Turvey
Journal: Journal of Experimental Medicine
Series: Genes and Immunity Focus
J Exp Med (2025) 223 (1): e20250939.
https://doi.org/10.1084/jem.20250939
Published: 21 November 2025
View article titled, Monogenic disorders of the IRF transcription factors
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Journal Articles

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Esmeralda Villavicencio Gonzalez, Huda Y. Zoghbi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241336.
https://doi.org/10.1084/jem.20241336
Published: 23 October 2025
View article titled, Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle
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Journal Articles

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

In Special Collection:
Neuroscience Collection 2025
Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250965.
https://doi.org/10.1084/jem.20250965
Published: 26 August 2025
View article titled, ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
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Journal Articles

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

In Special Collection:
Cytokines Collection 2025 , Hematopoietic Stem Cells and Myeloid Lineages in Health and Disease
Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M. Adrover
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20242402.
https://doi.org/10.1084/jem.20242402
Published: 11 August 2025
View article titled, Heart of the matter: Neutrophils, cancer, and cardiovascular disease
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Journal Articles

CD4+ T cell dysfunction in cancer

Hrishi Venkatesh, Lawrence Fong
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (9): e20241417.
https://doi.org/10.1084/jem.20241417
Published: 07 August 2025
View article titled, CD4+ T cell dysfunction in cancer
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Journal Articles

Lipid metabolism and neuroinflammation: What is the link?

In Special Collection:
Macrophages and Dendritic Cells in Health and Disease , Neuroscience Collection 2025
Vini Tiwari, Mikael Simons
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241232.
https://doi.org/10.1084/jem.20241232
Published: 05 August 2025
View article titled, Lipid metabolism and neuroinflammation: What is the link?
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Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241433.
https://doi.org/10.1084/jem.20241433
Published: 31 July 2025
View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells
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Journal Articles

YTHDFs as radiotherapy checkpoints in tumor immunity

In Special Collection:
JEM Cancer Immunotherapy 2025
Chuangyu Wen, Emile Z. Naccasha, Chuan He, Hua Laura Liang, Ralph R. Weichselbaum
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (8): e20250272.
https://doi.org/10.1084/jem.20250272
Published: 05 June 2025
View article titled, YTHDFs as radiotherapy checkpoints in tumor immunity
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Journal Articles

Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases

Natalia Reglero-Real, Loïc Rolas, Sussan Nourshargh
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242154.
https://doi.org/10.1084/jem.20242154
Published: 02 June 2025
View article titled, Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases
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Journal Articles

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Hanover C. Matz, Ali H. Ellebedy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241283.
https://doi.org/10.1084/jem.20241283
Published: 24 April 2025
View article titled, Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?
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Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:
JEM Clinical Immunology Collection 2025
Andrew A. Almonte, Simon Thomas, Laurence Zitvogel
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (7): e20250378.
https://doi.org/10.1084/jem.20250378
Published: 22 April 2025
View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies
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Journal Articles

Human immunity to fungal infections

In Special Collection:
JEM Clinical Immunology Collection 2025
Donald C. Vinh
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20241215.
https://doi.org/10.1084/jem.20241215
Published: 15 April 2025
View article titled, Human immunity to fungal infections
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