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Brief Definitive Report
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine
Lyu et al. demonstrate that microbiota-specific RORγt+ regulatory T cells are uniquely restrained by B7 costimulation. Blocking B7, or signal two, promotes RORγt+ regulatory T cells and protects from intestinal inflammation, but only when acting in concert with MHCII-dependent signal one from RORγt+ antigen-presenting cells.
Article
AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells
He et al. identify AID as a key initiator of plasma cell differentiation, beyond its established roles in SHM and CSR. They show that AID cooperates with TET2 to initiate plasma cell commitment by promoting demethylation of the Irf4 locus.
