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6 July 2026
In Progress
ISSN 0022-1007
EISSN 1540-9538
Brief Definitive Report
Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition
Evan W. Cody,Mehek Ningoo,Isha Monga,Alexander M. Tsankov,Hiromi Muramatsu,Norbert Pardi,Miguel Fribourg,Peter S. Heeger,David Dominguez-Sola
Memory B cell longevity underlies protection against reinfection. In this study, Cody et al. show that complement activation regulates memory B cell longevity in mice, shaping repertoire composition by modulating homeostatic proliferation and attrition of this B cell subset.
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