This review traces the separate discoveries of dendritic cells, cross-priming, and help for cytotoxic T cell responses. The authors document the gradual convergence of these discoveries into the current models of cell-mediated immunity, spotlighting unanswered questions and future directions.
As the first immune cells to colonize tissues and long-lived resident cells, macrophages play important roles in tissue functions during early development, homeostasis, and disease. Here, Chakarov et al. discuss macrophage origin and functions in adipose tissue and how these features are modulated in obesity.