Skip to Main Content

Advertisement

Issues

  • Cover Image

    Cover Image

    issue cover

    ON THE COVER
    Boyd et al. show that leukemic stem cells share their niches with normal hematopoietic stem cells in mouse BM. The image illustrates a portion of a mouse whole femur with leukemic stem cells concentrated in the endosteal region (red) among normal mouse BM cells (blue). Image provided by the authors.
    See page 1925

  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkEditorial Board
ISSN 0022-1007
EISSN 1540-9538
In this Issue

Insights

Brief Definitive Report

Spatial localization of primitive leukemic cells is restricted to niches shared with their normal counterparts, and their ability to retain occupancy of these niches is rivaled by normal HSPCs.

Ward et al. report retinal thinning in humans with progranulin mutations that precedes dementia onset, and an age-dependent retinal neurodegenerative phenotype in progranulin null mice. Nuclear depletion of TDP-43 precedes retinal neuronal loss and is accompanied by reduced GTPase Ran, with overexpression of Ran restoring nuclear TDP-43 and neuronal survival.

Naik et al. show that the deubiquitinating enzyme Usp9X is a regulator of T cell activation and its loss induces the development of a lupuslike autoimmune disease in mice.

Monocytes are required for arteriogenesis after injury and one of their major roles is to produce VEGF; however, the mechanisms behind this have not been identified. Morrison et al. find a link between chemokine and integrin stimulation through Rac2 that involves myosin heavy chain to redistribute the RNA stabilizing protein HuR to augment VEGF expression.

Genetic impairment of plasmacytoid dendritic cells ameliorates autoantibody production and symptoms of SLE in mice.

Article

Transient, genetic elimination of a specialized group of cells called plasmacytoid dendritic cells (pDCs) reverses many features of lupus in mice. Disease reduction was attributed in part to decreased expression of inflammatory molecules called interferons, which are produced primarily by pDCs.

Kovács et al. examine the role of the Src family kinases Hck, Fgr, and Lyn in immune cell–mediated inflammation. Using arthritis and skin inflammation models, the authors show that mice lacking hematopoietic Hck, Fgr, and Lyn are protected from these inflammatory diseases, showing loss of myeloid cell recruitment and lack of inflammatory mediator production. Unexpectedly, the three kinases are dispensable for the intrinsic migratory ability of myeloid cells. These finding may have clinical implications in rheumatic and skin diseases.

Ma et al. show that the Toxoplasma gondii polymorphic dense granule protein GRA6 triggers the activation of the host transcription factor NFAT4, thus affecting the host immune response and maximizing parasite virulence.

Common variable immunodeficiency (CVID) is characterized by abnormally low levels of antibodies in the blood and dysfunctional immune cells called CD4+ T cells. Perreau et al. now show evidence that bacteria-fighting CD4+ T cells in these patients are in a state of exhaustion due to a constant leakage of normal gut bacteria into the bloodstream, possibly due to insufficient antibody levels.

In humans infected with hepatitis B or C, high expression of a protein called T-bet in virus-fighting immune cells is associated with spontaneous clearance of the virus. Absence of T-bet was more often seen in patients whose infections became chronic.

Five potent and broadly anti-HIV neutralizing monoclonal antibodies are able to block infection by two different SHIVs in monkeys. The authors show that antibodies targeting the outer glycan coat were the most effective and determined that titers of roughly 1:100 protected half the animals.

Conti et al. show that IL-17 is produced by tongue-resident populations of γδ T cells and nTh17 cells in response to oropharyngeal candidiasis in mice.

Jacque et al. investigate the functions of NF-κB1 p105 and its associated NF-κB–binding partners in B cells, using a mutant mouse strain that carries a form of the NF-κB1 precursor that is resistant to IKK-induced proteolysis. They identify a critical B cell–intrinsic role for this IKK signaling pathway in the antigen-induced survival and differentiation of follicular mature B cells.

Heise et al. find that the NF-κB subunits c-REL and RELA in B cells play distinct roles during the germinal center reaction. While RELA stimulates the emergence of plasma cells from the germinal center, c-REL supports maintenance of the reaction over time, possibly by inducing a metabolic gene program connected to cell proliferation.

Xia et al. show that WASH deletion breaks the balance that controls self-renewal and differentiation of hematopoietic stem cells (HSCs). WASH assists the NURF complex to the promoter of c-Myc gene, and its loss perturbs LT-HSC differentiation by suppressing the transcriptional activation of c-Myc.

Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal