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Editorial

JEM's 2009 Tune-up

Heather L. Van Epps
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A challenge to Goliath

Mike Rossner
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In This Issue

Follicular T-to-be

Amy Maxmen
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Mast cells master a rash

Amy Maxmen
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HO-1's versatility

Amy Maxmen
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Bulldozing angiogenesis

Amy Maxmen
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People & Ideas

Shane Crotty: Exploring immune memory

Kira Heller

Virologist and published author Shane Crotty sees immune memory as the key to making a better vaccine.

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Commentary

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

Barbara A. Malynn,Averil Ma
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Brief Definitive Report

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

Roland Schmitz,Martin-Leo Hansmann,Verena Bohle,Jose Ignacio Martin-Subero,Sylvia Hartmann,Gunhild Mechtersheimer,Wolfram Klapper,Inga Vater,Maciej Giefing,Stefan Gesk,Jens Stanelle,Reiner Siebert,Ralf Küppers
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T follicular helper cells differentiate from Th2 cells in response to helminth antigens

Arielle Glatman Zaretsky,Justin J. Taylor,Irah L. King,Fraser A. Marshall,Markus Mohrs,Edward J. Pearce
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IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

Irah L. King,Markus Mohrs
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Identification and characterization of IL-10/IFN-γ–producing effector-like T cells with regulatory function in human blood

Barbara Häringer,Laura Lozza,Bodo Steckel,Jens Geginat
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A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

Tirtha Chakraborty,Thomas Perlot,Ramesh Subrahmanyam,Anant Jani,Peter H. Goff,Yu Zhang,Irina Ivanova,Frederick W. Alt,Ranjan Sen
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In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

Helen J. Lachmann,Philip Lowe,Sandra Daniela Felix,Christiane Rordorf,Kieron Leslie,Sheril Madhoo,Helmut Wittkowski,Stephan Bek,Nicole Hartmann,Sophie Bosset,Philip N. Hawkins,Thomas Jung
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Article

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

Yuumi Nakamura,Naotomo Kambe,Megumu Saito,Ryuta Nishikomori,Yun-Gi Kim,Makoto Murakami,Gabriel Núñez,Hiroyuki Matsue
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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

Isabelle Robert,Françoise Dantzer,Bernardo Reina-San-Martin
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The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription

Hong Ming Shen,Michael G. Poirier,Michael J. Allen,Justin North,Ratnesh Lal,Jonathan Widom,Ursula Storb
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Ikaros controls isotype selection during immunoglobulin class switch recombination

MacLean Sellars,Bernardo Reina-San-Martin,Philippe Kastner,Susan Chan
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M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

Yoshiaki Kubota,Keiyo Takubo,Takatsune Shimizu,Hiroaki Ohno,Kazuo Kishi,Masabumi Shibuya,Hideyuki Saya,Toshio Suda
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OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

Daniel Hirschhorn-Cymerman,Gabrielle A. Rizzuto,Taha Merghoub,Adam D. Cohen,Francesca Avogadri,Alexander M. Lesokhin,Andrew D. Weinberg,Jedd D. Wolchok,Alan N. Houghton
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Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1

Brandon F. Keele,Hui Li,Gerald H. Learn,Peter Hraber,Elena E. Giorgi,Truman Grayson,Chuanxi Sun,Yalu Chen,Wendy W. Yeh,Norman L. Letvin,John R. Mascola,Gary J. Nabel,Barton F. Haynes,Tanmoy Bhattacharya,Alan S. Perelson,Bette T. Korber,Beatrice H. Hahn,George M. Shaw
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Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

Anaïs Briot,Céline Deraison,Matthieu Lacroix,Chrystelle Bonnart,Aurélie Robin,Céline Besson,Pierre Dubus,Alain Hovnanian
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Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

Chun Geun Lee,Dominik Hartl,Gap Ryol Lee,Barbara Koller,Hiroshi Matsuura,Carla A. Da Silva,Myung Hyun Sohn,Lauren Cohn,Robert J. Homer,Alexander A. Kozhich,Alison Humbles,Jennifer Kearley,Anthony Coyle,Geoffrey Chupp,Jennifer Reed,Richard A. Flavell,Jack A. Elias
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Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production

Sotiria Tzima,Panayiotis Victoratos,Ksanthi Kranidioti,Maria Alexiou,George Kollias
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Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

Kuang-Hsiang Chuang,Saleh Altuwaijri,Gonghui Li,Jiann-Jyh Lai,Chin-Yi Chu,Kuo-Pao Lai,Hung-Yun Lin,Jong-Wei Hsu,Peter Keng,Ming-Chi Wu,Chawnshang Chang
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Correction

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

Meera G. Nair,Yurong Du,Jacqueline G. Perrigoue,Colby Zaph,Justin J. Taylor,Michael Goldschmidt,Gary P. Swain,George D. Yancopoulos,David M. Valenzuela,Andrew Murphy,Margaret Karow,Sean Stevens,Edward J. Pearce,David Artis
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Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease

John Wilson,Hannah Cullup,Rohan Lourie,Yonghua Sheng,Anna Palkova,Kristen J. Radford,Anne M. Dickinson,Alison M. Rice,Derek N.J. Hart,David J. Munster
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Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

Yuumi Nakamura,Naotomo Kambe,Megumu Saito,Ryuta Nishikomori,Yun-Gi Kim,Makoto Murakami,Gabriel Núñez,Hiroyuki Matsue
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Retraction

Role of interleukin 12 and costimulators in T cell anergy in vivo

Luk Van Parijs,Victor L. Perez,Andre Biuckians,Robert G. Maki,Cheryl A. London,Abul K. Abbas
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