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    A solitary multinucleated osteoclast is immunostained for the transcription factor microphthalmia (Mi). This protein, which localizes to the nucleus, is essential for normal osteoclast development. Rats harboring a deletion in Mi display severe osteopetrosis that improves with age. See related article in this issue by Weilbaecher et al., pp. 775–785.

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ISSN 0022-1007
EISSN 1540-9538
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