Plasma cells are abnormally located within the periarteriolar lymphoid sheaths (T cell area) of mouse spleen in TNF-R1–deficient mice and this phenotype is not restored after bone marrow reconstitution. The red fluorescence indicates IgM-positive cells and the green fluorescence reveals the Thy1-positive T cells. The bright red labeled–cells within the green areas are plasma cells. See related article in this issue by Tkachuk et al., pp. 469–477.
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Wegener's Granulomatosis: Anti–proteinase 3 Antibodies Are Potent Inductors of Human Endothelial Cell Signaling and Leakage Response
Brief Definitive Report