On the cover
A cross-section through the primitive streak of an early chick embryo shows how the cell adhesion protein β-dystroglycan (red) is down-regulated in epiblast cells undergoing epithelial-to-mesenchymal transition during gastrulation. Nakaya et al. reveal how this process is regulated by the CLASP family of microtubule plus-end tracking proteins. Nuclei are labeled green.
Image © 2013 Nakaya et al.
See page 637.
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Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A
The kinesin KIF4A is locally activated by the central spindle pool of Aurora B and thereby preferentially controls anaphase spindle length.
Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase
A gradient of Aurora B activity determines the distribution of the microtubule depolymerase Kif2A at the central spindle and specifies the subsequent spindle structure necessary for proper cytokinesis.
Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex
Disruption of the CLASP- and Dystroglycan-mediated cortical microtubule anchoring reduces epiblast–basement membrane interactions and initiates gastrulation.
The GEF Bcr promotes RhoA-dependent actin remodeling and MAL/SRF signaling in keratinocytes, which in turn promotes differentiation via regulation of desmoglein-1 expression.
Two Bruchpilot isoforms create a stereotypic arrangement of the cytomatrix that defines the size of the readily releasable pool of synaptic vesicles.
Atg18 phosphoregulation controls organellar dynamics by modulating its phosphoinositide-binding activity
Dephosphorylation of Atg18 increases its phosphoinositide-binding activity, thereby enhancing its association with the vacuolar membrane and inducing changes in vacuolar structure.
hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2
hGAAP promotes cell adhesion and migration by increasing localized Ca2+-dependent activation of calpain, leading to increased focal adhesion dynamics.