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    In an early Drosophila embryo stained for the nuclear envelope (green) and DNA (blue), hairy mRNA (magenta) accumulates in the apical cytoplasm. Dix et al. reveal that the Lissencephaly-1 protein promotes the recruitment of dynein and dynactin to hairy and other mRNA cargoes to facilitate their transport along microtubules.
    Image © 2013 Dix et al.
    See page 479.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Disease-related proteins regulate β1 integrin to limit cell contractility and maintain vascular integrity.

People & Ideas

Goldstein is studying the cell biology of how organisms develop.

Review

Report

The juxtaposition of a double-stranded DNA end and a short single-stranded DNA gap triggers robust activation of endogenous ATR and Chk1 mediated by DNA-PKcs.

Dephosphorylation of MEI-1 activates katanin during meiosis, whereas ubiquitin-mediated degradation of both MEI-1 and its activator PPFR-1 ensure efficient katanin inactivation during mitosis.

Tubulin glutamylating enzymes are important for beating behavior of ependymal cilia in the brain, whereas glycylating enzymes are critical for stability and maintenance of these cilia.

FRET-based sensors for cAMP and PKA activity reveal that mitochondrial subcompartments host segregated cAMP cascades with distinct functional and kinetic signatures.

Article

Aurora A phosphorylation-induced interaction of TACC3 and clathrin coordinates adjacent domains in each protein to create a microtubule-binding interface, whereas a distinct site in TACC3 recruits ch-TOG to mitotic spindles.

Lissencephaly-1 promotes the interaction of dynein with dynactin and facilitates motor complex association with mRNA cargos.

Phosphorylation of the scaffolding protein JIP1 serves as a molecular switch to coordinate anterograde and retrograde microtubule motor complexes involved in amyloid precursor protein transport.

The exocyst is recruited to secretory vesicles by the combinatorial signals of Sec4-GTP and the Snc proteins to confer both specificity and directionality to vesicular traffic.

Inclusion of IST1 into the ESCRT complex allows recruitment of the microtubule-severing protein spastin to promote fission of recycling tubules from the endosome.

Loss of CCM1/2 leads to destabilization of ICAP-1 and up-regulation of β1 integrin, resulting in the destabilization of intercellular junctions due to increased cell contractility and aberrant extracellular matrix remodeling.

Macrophages infiltrating the pancreas in response to inflammation induce cellular transdifferentiation by secreting cytokines that activate NF-κB signaling and matrix metalloproteinase expression.

Tools

A combination of RNase- and detergent-based preextraction with high-resolution microscopy allows the detection of Ku and other DNA repair proteins at single double-strand breaks in cells.

Correction

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