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Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores
Depletion analyses and nanometer-scale mapping of spindle assembly checkpoint proteins reveal how these proteins are integrated within the substructure of the kinetochore.
Neuronal injury induces JNK phosphorylation of DLK, which reduces DLK ubiquitination and creates a positive feedback loop to enhance JNK signaling and increase apoptosis.
PP2ACdc55 dephosphorylates APC/CCdc20 to prevent anaphase, an effect that is counteracted by Cdc28/Clbs to allow for spindle checkpoint adaptation.
Dynein and microtubule depolymerization drive centrosome repositioning in T cells via microtubule end-on capture-shrinkage operating at the center of the immunological synapse.
Drebrin activity in F-actin bundling and filopodia induction relies on two adjacent F-actin binding sites and a Cdk5 phosphorylation-regulated intramolecular inhibitory interaction.
α4β1 integrin promotes migration of fibroblast-like cells in confined environment by enhancing myosin IIA via Rac1 inhibition, whereas unconfined migration requires Rac1 and myosin IIB.