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    Cultured dorsal root ganglion neurons lacking the E3 ubiquitin ligase PHR1, which targets the kinase DLK for proteasomal degradation, display high levels of phosphorylation of the MAP kinase JNK (green) in their axons. Huntwork-Rodriguez et al. show that a rapid increase in the abundance of DLK protein occurs after neuronal injury and is important for initiation of downstream signaling events and neuronal apoptosis. Nuclei are labeled red.
    Image © 2013 Huntwork-Rodriguez et al.
    See page 747.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Study finds that cells alter movement style in tight spaces.

People & Ideas

Maiato studies how microtubule plus-end tracking proteins (+TIPs) influence mitosis.


Cell biology in neuroscience


Depletion analyses and nanometer-scale mapping of spindle assembly checkpoint proteins reveal how these proteins are integrated within the substructure of the kinetochore.


Neuronal injury induces JNK phosphorylation of DLK, which reduces DLK ubiquitination and creates a positive feedback loop to enhance JNK signaling and increase apoptosis.

PP2ACdc55 dephosphorylates APC/CCdc20 to prevent anaphase, an effect that is counteracted by Cdc28/Clbs to allow for spindle checkpoint adaptation.

Dynein and microtubule depolymerization drive centrosome repositioning in T cells via microtubule end-on capture-shrinkage operating at the center of the immunological synapse.

Drebrin activity in F-actin bundling and filopodia induction relies on two adjacent F-actin binding sites and a Cdk5 phosphorylation-regulated intramolecular inhibitory interaction.

α4β1 integrin promotes migration of fibroblast-like cells in confined environment by enhancing myosin IIA via Rac1 inhibition, whereas unconfined migration requires Rac1 and myosin IIB.


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