On the cover
Confocal microscopy shows the tail skin of a control mouse stained for keratin 14 (red) and DNA (blue). Niessen et al. reveal that, in the absence of atypical protein kinase Cλ, epidermal homeostasis and differentiation are disrupted due to an increase in asymmetric cell divisions.
Image © 2013 Niessen et al.
See page 887.
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In This Issue
Creating cellular inequality
Atypical protein kinase C sets the balance between asymmetrical and symmetrical divisions.
People & Ideas
Frances Brodsky: So you think you know all about clathrin?
Brodsky studies clathrin’s diverse biological functions.
pH sensing by FAK-His58 regulates focal adhesion remodeling
Increased intracellular pH is sensed by FAK-His58, which facilitates FAK autophosphorylation and focal adhesion remodeling.
Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases
The interaction of Ero1-α and PDI facilitates the electron transfer function of Ero1-α, activating a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.
Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport
The Drs2 flippase increases membrane curvature and anionic phospholipid composition of the membrane by flipping phosphatidylserine, which is critical for vesicular transport between the trans-Golgi network and early endosomes.
aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation
Loss of aPKCλ disrupts epidermal homeostasis and bulge stem cell maintenance by driving cell fate changes via a shift toward asymmetric division
Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization
Rap1 potentiates endothelial cell junctions by spatially controlling non-muscle myosin II activity through activation of the Cdc42–MRCK pathway and suppression of the Rho–ROCK pathway.
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex
RCP-driven α5β1 recycling suppresses Rac activity through the RacGAP1–IQGAP1 complex to permit local activation of RhoA and drive invasive migration.
SnoN facilitates ALK1–Smad1/5 signaling during embryonic angiogenesis
SnoN directly binds ALK1 on the plasma membrane, enhancing Smad1/5 activation, and is required for normal angiogenesis.
M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway
Mannose receptor–mediated uptake of collagen by M2-like macrophages is a major mechanism of collagen turnover in mice.
Biocompatible fluorescent silicon nanocrystals for single-molecule tracking and fluorescence imaging
Lack of photobleaching and blinking of new silicon nanocrystals allows direct observation of single-molecule receptor internalization and large-scale mosaicism in the plasma membrane.