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    On the cover
    Confocal microscopy shows the tail skin of a control mouse stained for keratin 14 (red) and DNA (blue). Niessen et al. reveal that, in the absence of atypical protein kinase Cλ, epidermal homeostasis and differentiation are disrupted due to an increase in asymmetric cell divisions.
    Image © 2013 Niessen et al.
    See page 887.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Atypical protein kinase C sets the balance between asymmetrical and symmetrical divisions.

People & Ideas

Brodsky studies clathrin’s diverse biological functions.


Cell biology in neuroscience


Increased intracellular pH is sensed by FAK-His58, which facilitates FAK autophosphorylation and focal adhesion remodeling.


The interaction of Ero1-α and PDI facilitates the electron transfer function of Ero1-α, activating a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.

The Drs2 flippase increases membrane curvature and anionic phospholipid composition of the membrane by flipping phosphatidylserine, which is critical for vesicular transport between the trans-Golgi network and early endosomes.

Loss of aPKCλ disrupts epidermal homeostasis and bulge stem cell maintenance by driving cell fate changes via a shift toward asymmetric division

Rap1 potentiates endothelial cell junctions by spatially controlling non-muscle myosin II activity through activation of the Cdc42–MRCK pathway and suppression of the Rho–ROCK pathway.

RCP-driven α5β1 recycling suppresses Rac activity through the RacGAP1–IQGAP1 complex to permit local activation of RhoA and drive invasive migration.

SnoN directly binds ALK1 on the plasma membrane, enhancing Smad1/5 activation, and is required for normal angiogenesis.

Mannose receptor–mediated uptake of collagen by M2-like macrophages is a major mechanism of collagen turnover in mice.


Lack of photobleaching and blinking of new silicon nanocrystals allows direct observation of single-molecule receptor internalization and large-scale mosaicism in the plasma membrane.

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