On the cover
Bärenz et al. demonstrate that the centriolar satellite protein SSX2IP promotes centrosome maturation. In contrast to the classic satellite marker PCM-1 (blue), SSX2IP (red) localizes to the spindle poles in mitotic cells. Spindle microtubules are shown in green and DNA in pink.
Image © 2013 Bärenz et al.
See page 81.
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Electron tomography and 3D modeling identifies augmin-dependent connections between the wall of one microtubule and the minus end of a neighboring one in the spindle.
Stable raftlike lipid domains form and segregate membrane proteins in the yeast vacuole in response to various stresses.
β-Catenin provides stability to epithelia exposed to mechanical stress in part by strengthening adherens junctions in response to tension.
Inhibition of mTORC1 leads to the degradation of high affinity HuD target mRNAs, freeing HuD to bind Kv1.1 mRNA and promote its translation by overcoming miR-129–mediated repression.
Two distinct lobes in the C-terminal inhibitory domain in STIM1 determine access of the inhibitor SARAF to the activating SOAR domain to regulate the slow Ca2+-dependent inactivation of Orai1.
SSX2IP promotes centrosome maturation and maintenance at the onset of vertebrate development, preserving centrosome integrity and mitosis during rapid cleavage divisions and in somatic cells.
Mitotic phosphorylation of Exo84 disrupts the assembly of the exocyst complex, thereby inhibiting exocytosis of select secreted cargoes and cell surface expansion.
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression
ARH is required for the trafficking of megalin from early endosomes to the endocytic recycling compartment, where megalin undergoes intramembrane proteolysis, releasing a tail fragment that represses megalin transcription.
Senescent cells extrude fragments of chromatin from the nucleus into the cytoplasm, where they are processed by an autophagic/lysosomal pathway.
Local palmitoylation machinery has an instructive role in creating activity-responsive PSD-95 nanodomains, which contribute to postsynaptic density (re)organization.
Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth
Vinculin functions as a molecular clutch that organizes leading edge F-actin, generates traction, and promotes focal adhesion formation and turnover but not adhesion growth.