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Cover Image
Cover Image
On the cover
Neural crest cells (red) migrate through a zebrafish embryo labeled for tubulin (green). Barriga et al. show that the hypoxia inducible factor Hif-1α controls neural crest migration by coordinating epithelial-to-mesenchymal transition and chemotaxis.
Image © 2013 Barriga et al.
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In This Issue
In Focus
Stem cells get a cholesterol test
Study reveals that dietary cholesterol regulates Hedgehog signaling and stem cell proliferation in flies.
People & Ideas
Alpha Yap: Cadherins hold it all together
Yap is interested in how cadherins influence the cytoskeleton—and vice versa.
Editorial
Report
Evolutionary comparisons reveal a positional switch for spindle pole oscillations in Caenorhabditis embryos
In one-cell stage embryos of different worm species, a conserved positional switch controls the onset of mitotic spindle oscillations, whereas the maximum amplitude of oscillations is determined by the time spent in the oscillating phase.
Formation and dissociation of proteasome storage granules are regulated by cytosolic pH
Cytosolic pH is a cellular signal involved both in the glucose sensing that mediates proteasome storage granule formation and in a more general mechanism for signaling carbon source exhaustion.
Live-cell imaging of exocyst links its spatiotemporal dynamics to various stages of vesicle fusion
Live-cell imaging of the exocyst subunit Sec8 reveals how the protein’s spatiotemporal dynamics correlate with its roles in vesicle fusion.
Keratins control intercellular adhesion involving PKC-α–mediated desmoplakin phosphorylation
Keratins limit PKC-α phosphorylation activity and desmosome turnover to ensure the stability of epithelial intracellular adhesion.
Article
The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
In mammalian cells, the phospho-dependent interaction between BRCA1 and CtIP is not required for homology-directed DNA repair or tumor suppression.
Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis
Spatial control of EB3 phosphorylation by Aurora B during mitotic exit regulates microtubule dynamics necessary for the stabilization of focal adhesions and coordinated daughter cell spreading, as well as for midbody stabilization and efficient cytokinesis.
Cryo–electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering
RIM1α-deficient synapses show structural defects in presynaptic vesicle distribution and tethering to the active zone that can be reversed by proteasome inhibition.
Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release
Dietary cholesterol levels control follicle stem cell proliferation in the Drosophila ovary via regulation of Hedgehog protein localization.
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition
Hif-1α is a novel and important regulator of EMT and chemotaxis during migration of neural crest cells.
