On the cover
Neural crest cells (red) migrate through a zebrafish embryo labeled for tubulin (green). Barriga et al. show that the hypoxia inducible factor Hif-1α controls neural crest migration by coordinating epithelial-to-mesenchymal transition and chemotaxis.
Image © 2013 Barriga et al.
See page 759.
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
In This Issue
People & Ideas
Evolutionary comparisons reveal a positional switch for spindle pole oscillations in Caenorhabditis embryos
In one-cell stage embryos of different worm species, a conserved positional switch controls the onset of mitotic spindle oscillations, whereas the maximum amplitude of oscillations is determined by the time spent in the oscillating phase.
Cytosolic pH is a cellular signal involved both in the glucose sensing that mediates proteasome storage granule formation and in a more general mechanism for signaling carbon source exhaustion.
Live-cell imaging of the exocyst subunit Sec8 reveals how the protein’s spatiotemporal dynamics correlate with its roles in vesicle fusion.
Keratins limit PKC-α phosphorylation activity and desmosome turnover to ensure the stability of epithelial intracellular adhesion.
The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression
In mammalian cells, the phospho-dependent interaction between BRCA1 and CtIP is not required for homology-directed DNA repair or tumor suppression.
Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis
Spatial control of EB3 phosphorylation by Aurora B during mitotic exit regulates microtubule dynamics necessary for the stabilization of focal adhesions and coordinated daughter cell spreading, as well as for midbody stabilization and efficient cytokinesis.
RIM1α-deficient synapses show structural defects in presynaptic vesicle distribution and tethering to the active zone that can be reversed by proteasome inhibition.
Dietary cholesterol levels control follicle stem cell proliferation in the Drosophila ovary via regulation of Hedgehog protein localization.
Hif-1α is a novel and important regulator of EMT and chemotaxis during migration of neural crest cells.