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In This Issue

In Focus

Study reveals that dietary cholesterol regulates Hedgehog signaling and stem cell proliferation in flies.

People & Ideas

Yap is interested in how cadherins influence the cytoskeleton—and vice versa.



In one-cell stage embryos of different worm species, a conserved positional switch controls the onset of mitotic spindle oscillations, whereas the maximum amplitude of oscillations is determined by the time spent in the oscillating phase.

Cytosolic pH is a cellular signal involved both in the glucose sensing that mediates proteasome storage granule formation and in a more general mechanism for signaling carbon source exhaustion.

Live-cell imaging of the exocyst subunit Sec8 reveals how the protein’s spatiotemporal dynamics correlate with its roles in vesicle fusion.

Keratins limit PKC-α phosphorylation activity and desmosome turnover to ensure the stability of epithelial intracellular adhesion.


In mammalian cells, the phospho-dependent interaction between BRCA1 and CtIP is not required for homology-directed DNA repair or tumor suppression.

Spatial control of EB3 phosphorylation by Aurora B during mitotic exit regulates microtubule dynamics necessary for the stabilization of focal adhesions and coordinated daughter cell spreading, as well as for midbody stabilization and efficient cytokinesis.

RIM1α-deficient synapses show structural defects in presynaptic vesicle distribution and tethering to the active zone that can be reversed by proteasome inhibition.

Dietary cholesterol levels control follicle stem cell proliferation in the Drosophila ovary via regulation of Hedgehog protein localization.

Hif-1α is a novel and important regulator of EMT and chemotaxis during migration of neural crest cells.


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