On the cover
During the development of C. elegans hermaphrodites, the uterine anchor cell (orange) invades through basement membrane (blue) to establish the uterine–vulval connection required for mating and egg laying. Hagedorn et al. demonstrate that localized netrin signaling focuses invadopodia-driven invasion by the anchor cell.
Image © 2013 Hagedorn et al.
See page 903.
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In This Issue
Means to an end
Bacteria use DNA segregation machinery to position polarity protein.
People & Ideas
Yukiko Yamashita: The centrosomes get there first
Yamashita studies how germline stem cells orient their asymmetric cell divisions.
RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response
RNF111/Arkadia targets SUMOylated XPC for ubiquitylation, negatively regulating its association with damaged DNA
Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins
In yeast, the localization of homologous recombination–associated proteins to heterochromatic regions of the genome is necessary for proper nuclear organization.
Spatiotemporal control of PopZ localization through cell cycle–coupled multimerization
ParA-dependent DNA segregation determines the cell cycle localization pattern of the pole-organizing protein PopZ by promoting its assembly into a matrix.
A Wee1 checkpoint inhibits anaphase onset
The budding yeast Wee1 kinase Swe1 restrains the metaphase-to-anaphase transition by preventing the Cdk1-dependent phosphorylation and activation of APCCdc20.
A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress
The GEF Tiam1 acts as a novel molecular link to the VE-cadherin–p67phox–Par3 polarity complex, leading to localized activation of Rac1 and NADPH oxidase in response to fluid flow.
The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
Localized Hippo signaling at contact sites between border cells induces polarized F-actin polymerization that drives collective cell migration.
Dynamic microtubules produce an asymmetric E-cadherin–Bazooka complex to maintain segment boundaries
The combined action of dynamic microtubules and Rho signaling determines the level and asymmetric distribution of a mobile E-cadherin–Bazooka complex during the generation of a patterned epithelium.
The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo
Localized activation of netrin signaling induces focused F-actin formation and the protrusive force necessary for physical displacement of basement membrane during cell transmigration.
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
Liprin-α2 is required for the presynaptic recruitment and turnover of RIM1 and CASK, components of the release machinery, and facilitates synaptic output by regulating synaptic vesicle pool size.
The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development
IgSF9b forms a novel subsynaptic domain for adhesion that links to the gephyrin- and GABAA receptor–containing domain to promote inhibitory synaptic development.
Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis
Injury-induced BMP signaling in the midgut negatively regulates intestinal stem cell division, whereas regional constitutive BMP signaling promotes copper cell differentiation.